PSB 1114

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Description: Potent, selective P2Y2 agonist
Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for PSB 1114

PSB 1114 is a potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.

Technical Data for PSB 1114

M. Wt 622.14
Formula C10H11F2N2Na4O13P3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1657025-60-9
PubChem ID 90488930
InChI Key KATPYMNMKKBLAH-GENVZAMMSA-J
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)C(O[C@@H]1COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)N1C=CC(=S)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSB 1114

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets for PSB 1114

Certificate of Analysis / Product Datasheet
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References for PSB 1114

References are publications that support the biological activity of the product.

El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878 PMID: 21417463


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Keywords: PSB 1114, PSB 1114 supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Purinergic, Receptors, 4333, Tocris Bioscience

2 Citations for PSB 1114

Citations are publications that use Tocris products. Selected citations for PSB 1114 include:

Ana C et al (2020) Vascular control of the CO2/H+-dependent drive to breathe. Elife 9 PMID: 32924935

Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088 PMID: 24553432


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.