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Submit ReviewPSB 1114
Description: Potent, selective P2Y2 agonist
Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Biological Activity for PSB 1114
PSB 1114 is a potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.
Technical Data for PSB 1114
| M. Wt | 622.14 |
| Formula | C10H11F2N2Na4O13P3S |
| Storage | Store at -80°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1657025-60-9 |
| PubChem ID | 90488930 |
| InChI Key | KATPYMNMKKBLAH-GENVZAMMSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)C(O[C@@H]1COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)N1C=CC(=S)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 1114
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for PSB 1114
References for PSB 1114
References are publications that support the biological activity of the product.
El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878 PMID: 21417463
If you know of a relevant reference for PSB 1114, please let us know.
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Keywords: PSB 1114, PSB 1114 supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Purinergic, Receptors, 4333, Tocris Bioscience
2 Citations for PSB 1114
Citations are publications that use Tocris products. Selected citations for PSB 1114 include:
Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088 PMID: 24553432
Ana C et al (2020) Vascular control of the CO2/H+-dependent drive to breathe. Elife 9 PMID: 32924935
Do you know of a great paper that uses PSB 1114 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.