Potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
Preparing Stock Solutions
The following data is based on the product molecular weight 622.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.61 mL||8.04 mL||16.07 mL|
|5 mM||0.32 mL||1.61 mL||3.21 mL|
|10 mM||0.16 mL||0.8 mL||1.61 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References are publications that support the biological activity of the product.
El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878 PMID: 21417463
If you know of a relevant reference for PSB 1114, please let us know.
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Keywords: PSB 1114, PSB 1114 supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Purinergic, Receptors, 4333, Tocris Bioscience
1 Citation for PSB 1114
Citations are publications that use Tocris products. Selected citations for PSB 1114 include:
Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088 PMID: 24553432
Do you know of a great paper that uses PSB 1114 from Tocris? Please let us know.
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