PSB 1114

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Cat.No. 4333 - PSB 1114 | C10H11F2N2Na4O13P3S | CAS No. 1657025-60-9
Description: Potent, selective P2Y2 agonist
Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.

Technical Data

M. Wt 622.14
Formula C10H11F2N2Na4O13P3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1657025-60-9
PubChem ID 90488930
InChI Key KATPYMNMKKBLAH-GENVZAMMSA-J
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)C(O[C@@H]1COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)N1C=CC(=S)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 622.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.04 mL 16.07 mL
5 mM 0.32 mL 1.61 mL 3.21 mL
10 mM 0.16 mL 0.8 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878 PMID: 21417463


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Keywords: PSB 1114, supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

1 Citation for PSB 1114

Citations are publications that use Tocris products. Selected citations for PSB 1114 include:

Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088 PMID: 24553432


Do you know of a great paper that uses PSB 1114 from Tocris? If so please let us know.

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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

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Pathways for PSB 1114

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