MRS 2905

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Cat.No. 5633 - MRS 2905 | C10H13N2Na3O10P2S
Description: Potent and selective P2Y14 receptor agonist
Chemical Name: 2-Thiouridine-5'-O-(α, β-methylene)diphosphate trisodium salt
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6.

Technical Data

M. Wt 484.2
Formula C10H13N2Na3O10P2S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513874
Smiles O[C@H]1[C@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(CP(O[Na])(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 21.79 45

Preparing Stock Solutions

The following data is based on the product molecular weight 484.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.33 mL 20.65 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 53 471 PMID: 19902968

Lazarowski et al (2015) UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y14 receptor activation. Mol.Pharmacol. 88 151 PMID: 25829059

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Keywords: MRS2905 Potent selective P2Y14 receptors agonists agonism Purinergic P2Y Receptors

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