MRS 2905

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Description: Potent and selective P2Y14 receptor agonist
Chemical Name: 2-Thiouridine-5'-O-(α, β-methylene)diphosphate trisodium salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for MRS 2905

MRS 2905 is a potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6.

Technical Data for MRS 2905

M. Wt 484.2
Formula C10H13N2Na3O10P2S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513874
Smiles O[C@H]1[C@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(CP(O[Na])(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRS 2905

Solvent Max Conc. mg/mL Max Conc. mM
water 21.79 45

Preparing Stock Solutions for MRS 2905

The following data is based on the product molecular weight 484.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.45 mM 4.59 mL 22.95 mL 45.89 mL
2.25 mM 0.92 mL 4.59 mL 9.18 mL
4.5 mM 0.46 mL 2.29 mL 4.59 mL
22.5 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets for MRS 2905

Certificate of Analysis / Product Datasheet
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References for MRS 2905

References are publications that support the biological activity of the product.

Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 53 471 PMID: 19902968

Lazarowski et al (2015) UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y14 receptor activation. Mol.Pharmacol. 88 151 PMID: 25829059

If you know of a relevant reference for MRS 2905, please let us know.

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Citations for MRS 2905

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.