MRS 2768 tetrasodium salt

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Cat.No. 3884 - MRS 2768 tetrasodium salt | C15H16N2O18P4Na4 | CAS No. 1047980-83-5
Description: Selective P2Y2 agonist
Chemical Name: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Selective P2Y2 agonist (EC50 = 1.89 μM). Displays no affinity for human P2Y4 or P2Y6 receptors.

Technical Data

M. Wt 728.14
Formula C15H16N2O18P4Na4
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 1047980-83-5
PubChem ID 90488893
InChI Key ASYFBNZFGLWLNC-YYXHNCPRSA-J
Smiles [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC1=CC=CC=C1)N1C=CC(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319 PMID: 18514530


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4 Citations for MRS 2768 tetrasodium salt

Citations are publications that use Tocris products. Selected citations for MRS 2768 tetrasodium salt include:

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730

Trabanelli et al (2012) Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol 189 1303 PMID: 22753942

Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID: 24310605

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. PLoS Comput Biol 305 F396 PMID: 23720349


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Literature in this Area

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