OGT 2115

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Cat.No. 2710 - OGT 2115 | C24H16BrFN2O4 | CAS No. 853929-59-6
Description: Antiangiogenic. Heparanase inhibitor
Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).

Technical Data

M. Wt 495.3
Formula C24H16BrFN2O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 853929-59-6
PubChem ID 44402523
InChI Key LKBXWNYXDMSFQU-ONNFQVAWSA-N
Smiles O=C(/C=C/C4=CC=C(Br)C=C4)NC(C(F)=C3)=CC=C3C2=NC1=CC(CC(O)=O)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.95 10

Preparing Stock Solutions

The following data is based on the product molecular weight 495.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.19 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1 PMID: 17339837

Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295 PMID:


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Keywords: Antiangiogenic Heparanase inhibitors inhibits Antiangiogenics Glycosylases Carbohydrate Metabolism OGT2115 Antiangiogenics

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for OGT 2115

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