OGT 2115

Pricing Availability   Qty
Cat.No. 2710 - OGT 2115 | C24H16BrFN2O4 | CAS No. 853929-59-6
Description: Antiangiogenic. Heparanase inhibitor
Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (2)

Biological Activity

Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).

Technical Data

M. Wt 495.3
Formula C24H16BrFN2O4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 853929-59-6
PubChem ID 44402523
InChI Key LKBXWNYXDMSFQU-ONNFQVAWSA-N
Smiles O=C(/C=C/C4=CC=C(Br)C=C4)NC(C(F)=C3)=CC=C3C2=NC1=CC(CC(O)=O)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.95 10

Preparing Stock Solutions

The following data is based on the product molecular weight 495.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.19 mL 100.95 mL 201.9 mL
0.5 mM 4.04 mL 20.19 mL 40.38 mL
1 mM 2.02 mL 10.09 mL 20.19 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1 PMID: 17339837

Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295


If you know of a relevant reference for OGT 2115, please let us know.

Keywords: OGT 2115, OGT 2115 supplier, Antiangiogenic, Heparanase, inhibitors, inhibits, Antiangiogenics, Glycosylases, Carbohydrate, Metabolism, OGT2115, Cell, Adhesion, Molecules, 2710, Tocris Bioscience

4 Citations for OGT 2115

Citations are publications that use Tocris products. Selected citations for OGT 2115 include:

Whitehead (2018) Heparanase attenuates axon degeneration following sciatic nerve transection. Sci Rep 8 5219 PMID: 29581478

Changyaleket et al (2017) Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats. J Neuroinflammation 14 137 PMID: 28720149

Agelidis et al (2017) Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep 20 439 PMID: 28700944

Glasner (2017) Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. PLoS Pathogens 13 e1006673 PMID: 29121099


Do you know of a great paper that uses OGT 2115 from Tocris? Please let us know.

Reviews for OGT 2115

There are currently no reviews for this product. Be the first to review OGT 2115 and earn rewards!

Have you used OGT 2115?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.