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Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 495.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.19 mL||100.95 mL||201.9 mL|
|0.5 mM||4.04 mL||20.19 mL||40.38 mL|
|1 mM||2.02 mL||10.09 mL||20.19 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
References are publications that support the biological activity of the product.
McKenzie (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 151 1 PMID: 17339837
Courtney et al (2005) Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts. 15 2295
If you know of a relevant reference for OGT 2115, please let us know.
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Keywords: OGT 2115, OGT 2115 supplier, Antiangiogenic, Heparanase, inhibitors, inhibits, Antiangiogenics, Glycosylases, Carbohydrate, Metabolism, OGT2115, Cell, Adhesion, Molecules, 2710, Tocris Bioscience
4 Citations for OGT 2115
Citations are publications that use Tocris products. Selected citations for OGT 2115 include:
Whitehead (2018) Heparanase attenuates axon degeneration following sciatic nerve transection. Sci Rep 8 5219 PMID: 29581478
Changyaleket et al (2017) Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats. J Neuroinflammation 14 137 PMID: 28720149
Agelidis et al (2017) Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Rep 20 439 PMID: 28700944
Glasner (2017) Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. PLoS Pathogens 13 e1006673 PMID: 29121099
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Literature in this Area
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