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Biological Activity for A 286982
A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).
Compound Libraries for A 286982
Technical Data for A 286982
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 286982
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for A 286982
The following data is based on the product molecular weight 453.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11.02 mL||22.05 mL|
|5 mM||0.44 mL||2.2 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for A 286982
References are publications that support the biological activity of the product.
Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025 PMID: 11052808
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Keywords: A 286982, A 286982 supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Integrins, Cell, Adhesion, Molecules, 4228, Tocris Bioscience
1 Citation for A 286982
Citations are publications that use Tocris products. Selected citations for A 286982 include:
Jon M et al (2019) Approaches for investigating the extracellular signaling function of ISG15. Methods Enzymol 618 211-227 PMID: 30850053
Do you know of a great paper that uses A 286982 from Tocris? Please let us know.
Reviews for A 286982
Average Rating: 5 (Based on 1 Review.)
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alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.
Literature in this Area
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