A 286982

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Cat.No. 4228 - A 286982 | C24H27N3O4S | CAS No. 280749-17-9
Description: Potent inhibitor of the LFA-1/ICAM-1 interaction
Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Compound Libraries

A 286982 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 453.55
Formula C24H27N3O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 280749-17-9
PubChem ID 9846729
InChI Key HTGGAYLWTDOFDK-PKNBQFBNSA-N
Smiles O=C(C)N1CCN(C(/C=C/C2=CC([N+]([O-])=O)=C(SC3=CC=CC=C3C(C)C)C=C2)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.35 100
ethanol 22.68 50

Preparing Stock Solutions

The following data is based on the product molecular weight 453.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025 PMID: 11052808


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Keywords: A 286982, A 286982 supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Integrins, Cell, Adhesion, Molecules, 4228, Tocris Bioscience

Citations for A 286982

Citations are publications that use Tocris products.

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Reviews for A 286982

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A 286982 was used to inhibit the action of LFA-1 ( alpha L beta 2) and measure effects.
By Anonymous on 02/26/2019
Species: Human

alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.

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Literature in this Area

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Enabling Research By Provision of Chemical Tools

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.