A 286982

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Cat.No. 4228 - A 286982 | C24H27N3O4S | CAS No. 280749-17-9
Description: Potent inhibitor of the LFA-1/ICAM-1 interaction
Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Technical Data

M. Wt 453.55
Formula C24H27N3O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 280749-17-9
PubChem ID 9846729
InChI Key HTGGAYLWTDOFDK-PKNBQFBNSA-N
Smiles O=C(C)N1CCN(C(/C=C/C2=CC([N+]([O-])=O)=C(SC3=CC=CC=C3C(C)C)C=C2)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.35 100
ethanol 22.68 50

Preparing Stock Solutions

The following data is based on the product molecular weight 453.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025 PMID: 11052808


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Keywords: A 286982, supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Integrins, Tocris Bioscience

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Literature in this Area

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
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  • Immune Cell Signaling
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