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Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Purity: ≥95% (HPLC)
Citations (5)

Biological Activity for Ac2-26

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Technical Data for Ac2-26

M. Wt 3089.46
Formula C141H210N32O44S

(Modifications: Ala-1 = N-terminal Ac)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 151988-33-9
PubChem ID 16138723
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac2-26

Solubility Soluble to 1 mg/ml in PBS

Product Datasheets for Ac2-26

Certificate of Analysis / Product Datasheet
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References for Ac2-26

References are publications that support the biological activity of the product.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306 PMID: 8409403

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854

Silistino-Souza et al (2007) Annexin 1: differential expression in tumor and mast cells in human larynx cancer Int.J.Cancer 120 2582 PMID: 17340616

Cardin et al (2019) Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis. FEBS Open Bio 9 668 PMID: 30984541

If you know of a relevant reference for Ac2-26, please let us know.

Keywords: Ac2-26, Ac2-26 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1845, Tocris Bioscience

5 Citations for Ac2-26

Citations are publications that use Tocris products. Selected citations for Ac2-26 include:

Fredman et al (2015) Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med 7 275ra20 PMID: 25695999

Brancaleone et al (2011) Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol 186 4905 PMID: 21398608

Pessolano et al (2019) Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs. Cells 8 PMID: 31331117

Leoni et al (2015) Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. Hum Mol Genet 97 87 PMID: 25395303

Do you know of a great paper that uses Ac2-26 from Tocris? Please let us know.

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