Ac2-26

Pricing Availability Delivery Time Qty
Cat.No. 1845 - Ac2-26 | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys | CAS No. 151988-33-9
Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Datasheet
Citations (4)
Literature

Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M. Wt 3089.46
Formula C141H210N32O44S
Sequence AMVSEFLKQAWFIENEEQEYVQTVK

(Modifications: Ala-1 = N-terminal Ac)

Storage Desiccate at -20°C
CAS Number 151988-33-9
PubChem ID 16138723
InChI Key ODWGEWZOPBDSHW-ISLQBSBZSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in PBS

Preparing Stock Solutions

The following data is based on the product molecular weight 3089.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.32 mL 1.62 mL 3.24 mL
5 mM 0.06 mL 0.32 mL 0.65 mL
10 mM 0.03 mL 0.16 mL 0.32 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306 PMID: 8409403

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854


If you know of a relevant reference for Ac2-26, please let us know.

Keywords: Ac2-26, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, Adhesion, Molecules, Cell, Adhesion, Molecules, Tocris Bioscience

4 Citations for Ac2-26

Citations are publications that use Tocris products. Selected citations for Ac2-26 include:

Dalli et al (2012) Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol 3 28 PMID: 22403546

Brancaleone et al (2011) Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol 186 4905 PMID: 21398608

Fredman et al (2015) Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med 7 275ra20 PMID: 25695999

Leoni et al (2015) Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. Hum Mol Genet 97 87 PMID: 25395303


Do you know of a great paper that uses Ac2-26 from Tocris? If so please let us know.

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