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Submit ReviewRGDS peptide
Description: Integrin binding sequence; inhibits integrin receptor function
Biological Activity
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
Technical Data
| M. Wt | 433.42 |
| Formula | C15H27N7O8 |
| Sequence | RGDS |
| Storage | Desiccate at -20°C |
| CAS Number | 91037-65-9 |
| PubChem ID | 107775 |
| InChI Key | NNRFRJQMBSBXGO-CIUDSAMLSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733 PMID: 15522882
Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18 PMID: 19272161
Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551 PMID: 19276073
If you know of a relevant reference for RGDS peptide, please let us know.
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Keywords: RGDS peptide, RGDS peptide supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules, Cell, Integrins, 3498, Tocris Bioscience
7 Citations for RGDS peptide
Citations are publications that use Tocris products. Selected citations for RGDS peptide include:
Conant (2017) Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation 14 56 PMID: 28302163
Kang et al (2012) Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci 32 9277 PMID: 22764235
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Ahmed et al (2015) Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells. J Radiat Res 2 85 PMID: 25692127
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature 557 714 PMID: 29795344
Bian et al (2017) Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res 5 17008 PMID: 28392965
Do you know of a great paper that uses RGDS peptide from Tocris? Please let us know.
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