RGDS peptide

Pricing Availability   Qty
Description: Integrin binding sequence; inhibits integrin receptor function
Purity: ≥95% (HPLC)
Datasheet
Citations (14)
Reviews (2)
Literature (2)

Biological Activity for RGDS peptide

RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.

Technical Data for RGDS peptide

M. Wt 433.42
Formula C15H27N7O8
Sequence RGDS
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 91037-65-9
PubChem ID 107775
InChI Key NNRFRJQMBSBXGO-CIUDSAMLSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RGDS peptide

Solubility Soluble to 1 mg/ml in water

Product Datasheets for RGDS peptide

Certificate of Analysis / Product Datasheet
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References for RGDS peptide

References are publications that support the biological activity of the product.

Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733 PMID: 15522882

Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18 PMID: 19272161

Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551 PMID: 19276073


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Keywords: RGDS peptide, RGDS peptide supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules, Cell, Integrins, 3498, Tocris Bioscience

14 Citations for RGDS peptide

Citations are publications that use Tocris products. Selected citations for RGDS peptide include:

Ahmed et al (2015) Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells. J Radiat Res 2 85 PMID: 25692127

Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114

Bian et al (2017) Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res 5 17008 PMID: 28392965

Conant (2017) Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation 14 56 PMID: 28302163

Sean P et al (2018) Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell 34 659-673.e6 PMID: 30270124

Yan et al (2016) Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism. Eur J Neurosci 43 194-203 PMID: 26660285

Kang et al (2012) Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci 32 9277 PMID: 22764235

Marko et al (2022) The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis. Front Oncol 12 777634 PMID: 35211397

Anne et al (2022) Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina. Dev Cell 57 2321-2333.e9 PMID: 36220082

Tao et al (2022) Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy. Adv Sci (Weinh) 9 e2104469 PMID: 35166070

Pradyut K et al (2022) Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment. Stem Cells Transl Med 11 630-643 PMID: 35438788

Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature 557 714 PMID: 29795344

Paul C et al (2020) β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Sci Rep 10 12644 PMID: 32724089

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828


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Reviews for RGDS peptide

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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By Anonymous on 03/24/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat astroglioma C6 cells

Co-incubated with RGDS 10 µg/ml

PMID: 29222114
review image

Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse brain endothelioma cell line

100 μg/ml

PMID: 27978828
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.