A 205804

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Description: Selective inhibitor of E-selectin and ICAM-1 expression
Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (3)

Biological Activity for A 205804

A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Technical Data for A 205804

M. Wt 300.39
Formula C15H12N2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 251992-66-2
PubChem ID 9839311
InChI Key QQGWEXFLMJGCAL-UHFFFAOYSA-N
Smiles CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 205804

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 3 10

Preparing Stock Solutions for A 205804

The following data is based on the product molecular weight 300.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Keywords: A 205804, A 205804 supplier, Selective, inhibitors, inhibits, E-selectin, ICAM-1, Adhesion, Molecules, A205804, Cell, Integrins, 2524, Tocris Bioscience

1 Citation for A 205804

Citations are publications that use Tocris products. Selected citations for A 205804 include:

Othumpangat et al (2016) ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection. Virology 487 85 PMID: 26499045


Do you know of a great paper that uses A 205804 from Tocris? Please let us know.

Reviews for A 205804

Average Rating: 5 (Based on 1 Review.)

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ICAM-1 inhibitor A 205804 show the highest increase in matrix copy number.
By Anonymous on 10/20/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HBEpC

We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A205804(TOCRIS),whereas 50ng/mL showed the highest(100%)increase in matrix copy number compared to the DMSO treatedcontrol cells infected with influenza virus

PMID: 26499045
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.