A 205804

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Cat.No. 2524 - A 205804 | C15H12N2OS2 | CAS No. 251992-66-2
Description: Selective inhibitor of E-selectin and ICAM-1 expression
Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Compound Libraries

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Technical Data

M. Wt 300.39
Formula C15H12N2OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 251992-66-2
PubChem ID 9839311
InChI Key QQGWEXFLMJGCAL-UHFFFAOYSA-N
Smiles CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 3 10

Preparing Stock Solutions

The following data is based on the product molecular weight 300.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References

References are publications that support the biological activity of the product.

Stewart et al (2001) Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J.Med.Chem. 44 988 PMID: 11300880

Zhu et al (2001) Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J.Med.Chem. 44 3469 PMID: 11585452

Zhu et al (2002) Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. J.Org.Chem. 67 943 PMID: 11856042


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Keywords: A 205804, A 205804 supplier, Selective, inhibitors, inhibits, E-selectin, ICAM-1, Adhesion, Molecules, A205804, Cell, Integrins, 2524, Tocris Bioscience

1 Citation for A 205804

Citations are publications that use Tocris products. Selected citations for A 205804 include:

Othumpangat et al (2016) ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection. Virology 487 85 PMID: 26499045


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Literature in this Area

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