BTT 3033

Pricing Availability Delivery Time Qty
Cat.No. 4724 - BTT 3033 | C23H20FN5O3S | CAS No. 1259028-99-3
Description: Selective inhibitor of integrin α2β1
Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions.

Compound Libraries

BTT 3033 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 465.5
Formula C23H20FN5O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1259028-99-3
PubChem ID 49841251
InChI Key NSLIQOPYDUKWTA-UHFFFAOYSA-N
Smiles FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nissinen et al (2012) Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694 PMID: 23132859


If you know of a relevant reference for BTT 3033, please let us know.

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: BTT3033 selective inhibitors inhibits integrins receptors alpha2beta1 α2β1 a2b1 collagen 1 cell adhesion Integrins

Citations for BTT 3033

Citations are publications that use Tocris products.

Currently there are no citations for BTT 3033. Do you know of a great paper that uses BTT 3033 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for BTT 3033

Protocols

TODO: Add Protocols