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Selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Nissinen et al (2012) Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694 PMID: 23132859
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Keywords: BTT 3033, BTT 3033 supplier, BTT3033, selective, inhibitors, inhibits, integrins, receptors, alpha2beta1, α2β1, a2b1, collagen, 1, cell, adhesion, Integrins, Cell, Adhesion, Molecules, 4724, Tocris Bioscience
1 Citation for BTT 3033
Citations are publications that use Tocris products. Selected citations for BTT 3033 include:
Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep 8 696 PMID: 29330408
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Literature in this Area
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