Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.66 mL||13.32 mL||26.64 mL|
|5 mM||0.53 mL||2.66 mL||5.33 mL|
|10 mM||0.27 mL||1.33 mL||2.66 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References are publications that support the biological activity of the product.
Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927
Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994
Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408
If you know of a relevant reference for KF 38789, please let us know.
Keywords: KF 38789, KF 38789 supplier, Selective, inhibitors, inhibits, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789, Cell, 2748, Tocris Bioscience
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