KF 38789

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Description: Selective inhibitor of P-selectin-mediated cell adhesion
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Purity: ≥97% (HPLC)
Citations (3)
Reviews (1)

Biological Activity for KF 38789

KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF 38789 blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Compound Libraries for KF 38789

KF 38789 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for KF 38789

M. Wt 375.44
Formula C19H21NO5S
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 257292-29-8
PubChem ID 5373277
Smiles COC1=CC=C(C2CC(=NCCS2)C2=C(O)C=C(C)OC2=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KF 38789

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.54 100

Preparing Stock Solutions for KF 38789

The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for KF 38789

Certificate of Analysis / Product Datasheet
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References for KF 38789

References are publications that support the biological activity of the product.

Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927

Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994

Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408

If you know of a relevant reference for KF 38789, please let us know.

Keywords: KF 38789, KF 38789 supplier, Selective, inhibitors, inhibits, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789, Cell, 2748, Tocris Bioscience

3 Citations for KF 38789

Citations are publications that use Tocris products. Selected citations for KF 38789 include:

Zhao et al (2017) Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med 21 1523 PMID: 28211187

Neufeld et al (2021) Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment Sci Adv 7 eabi9119 PMID: 34407932

Li et al (2019) Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat Commun 10 2406 PMID: 31160622

Do you know of a great paper that uses KF 38789 from Tocris? Please let us know.

Reviews for KF 38789

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We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.
By Meghan Bradshaw on 02/20/2019
Species: Human

We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.

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