KF 38789

Pricing Availability   Qty
Cat.No. 2748 - KF 38789 | C19H21NO5S | CAS No. 257292-29-8
Description: Selective inhibitor of P-selectin-mediated cell adhesion
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Compound Libraries

KF 38789 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 375.44
Formula C19H21NO5S
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 257292-29-8
PubChem ID 5373277
InChI Key FJDFKOSFDPIMBV-NBVRZTHBSA-N
Smiles COC1=CC=C(C2CC(=NCCS2)C2=C(O)C=C(C)OC2=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927

Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994

Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408


If you know of a relevant reference for KF 38789, please let us know.

Keywords: KF 38789, KF 38789 supplier, Selective, inhibitors, inhibits, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789, Cell, 2748, Tocris Bioscience

2 Citations for KF 38789

Citations are publications that use Tocris products. Selected citations for KF 38789 include:

Li et al (2019) Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat Commun 10 2406 PMID: 31160622

Zhao et al (2017) Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med 21 1523 PMID: 28211187


Do you know of a great paper that uses KF 38789 from Tocris? Please let us know.

Reviews for KF 38789

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used KF 38789?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.
By Meghan Bradshaw on 02/20/2019
Species: Human

We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis