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Biological Activity for GLPG 0187
GLPG 0187 is a potent αv integrin inhibitor (IC50 values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.
Technical Data for GLPG 0187
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GLPG 0187
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GLPG 0187
The following data is based on the product molecular weight 595.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.79 mL||83.93 mL||167.87 mL|
|0.5 mM||3.36 mL||16.79 mL||33.57 mL|
|1 mM||1.68 mL||8.39 mL||16.79 mL|
|5 mM||0.34 mL||1.68 mL||3.36 mL|
References for GLPG 0187
References are publications that support the biological activity of the product.
van der Horst, et al (2011) Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 13 516 PMID: 21677875
Silginer et al (2014) Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 5 e1012 PMID: 24457956
If you know of a relevant reference for GLPG 0187, please let us know.
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Keywords: GLPG 0187, GLPG 0187 supplier, GLPG0187, αv, integrins, inhibitors, inhibitor, inhibits, inhibit, epithelial-mesenchymal, transition, EMT, osteoclastic, bone, resorption, Integrins, Cell, Adhesion, Molecules, 7059, Tocris Bioscience
Citations for GLPG 0187
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Currently there are no citations for GLPG 0187. Do you know of a great paper that uses GLPG 0187 from Tocris? Please let us know.
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Literature in this Area
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