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GLPG 0187 is a potent αv integrin inhibitor (IC50 values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 595.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.79 mL||83.93 mL||167.87 mL|
|0.5 mM||3.36 mL||16.79 mL||33.57 mL|
|1 mM||1.68 mL||8.39 mL||16.79 mL|
|5 mM||0.34 mL||1.68 mL||3.36 mL|
References are publications that support the biological activity of the product.
van der Horst, et al (2011) Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 13 516 PMID: 21677875
Silginer et al (2014) Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 5 e1012 PMID: 24457956
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Keywords: GLPG 0187, GLPG 0187 supplier, GLPG0187, αv, integrins, inhibitors, inhibitor, inhibits, inhibit, epithelial-mesenchymal, transition, EMT, osteoclastic, bone, resorption, Integrins, Cell, Adhesion, Molecules, 7059, Tocris Bioscience
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