Pricing Availability   Qty
Description: Fluorescent ligand for α4β1 (VLA-4)
Purity: ≥90% (HPLC)
Citations (1)
Literature (1)

Biological Activity for LDV FITC

LDV FITC is a fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

Technical Data for LDV FITC

M. Wt 1368.54
Formula C69H81N11O17S
Sequence LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1207610-07-8
PubChem ID 91826076
Smiles CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(C(O)=O)c(c1)-c1c-2ccc(=O)cc-2oc2cc(O)ccc12)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LDV FITC

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Product Datasheets for LDV FITC

Certificate of Analysis / Product Datasheet
Select another batch:

References for LDV FITC

References are publications that support the biological activity of the product.

Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670 PMID: 11641394

Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507 PMID: 19754304

Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951 PMID: 14645084

If you know of a relevant reference for LDV FITC, please let us know.

Keywords: LDV FITC, LDV FITC supplier, LDVFITC, VLA-4, very, late, antigen, VLA4, integrins, alpha4beta1, a4b1, α4, β1, fluorescent, ligands, TR-FRET, acceptor, Fluorescent, Receptor, Probes, Integrins, Cell, Adhesion, Molecules, Integrin, and, FP, Assay, Reagents, 4577, Tocris Bioscience

1 Citation for LDV FITC

Citations are publications that use Tocris products. Selected citations for LDV FITC include:

Scott I et al (2013) On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction. Proc Natl Acad Sci U S A 110 13944-9 PMID: 23918401

Do you know of a great paper that uses LDV FITC from Tocris? Please let us know.

Reviews for LDV FITC

There are currently no reviews for this product. Be the first to review LDV FITC and earn rewards!

Have you used LDV FITC?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals