LDV FITC

Pricing Availability Delivery Time Qty
Cat.No. 4577 - LDV FITC | N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu-Asp-Val-Pro-Ala-Ala-Lys-FITC | CAS No. 1207610-07-8
Description: Fluorescent ligand for α4β1 (VLA-4)
Datasheet
Citations
Reviews
Literature

Biological Activity

Fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes.

Technical Data

M. Wt 1368.54
Formula C69H81N11O17S
Sequence LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)
Storage Store at -20°C
CAS Number 1207610-07-8
PubChem ID 91826076
InChI Key PAAUNHNWVWSJKI-CBRXRBRLSA-N
Smiles CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(C(O)=O)c(c1)-c1c-2ccc(=O)cc-2oc2cc(O)ccc12)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 1368.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.73 mL 3.65 mL 7.31 mL
5 mM 0.15 mL 0.73 mL 1.46 mL
10 mM 0.07 mL 0.37 mL 0.73 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670 PMID: 11641394

Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507 PMID: 19754304

Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951 PMID: 14645084


If you know of a relevant reference for LDV FITC, please let us know.

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Citations for LDV FITC

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Literature in this Area

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