LDV FITC

Pricing Availability   Qty
Cat.No. 4577 - LDV FITC | N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu-Asp-Val-Pro-Ala-Ala-Lys-FITC | CAS No. 1207610-07-8
Description: Fluorescent ligand for α4β1 (VLA-4)
Datasheet
Citations
Reviews
Literature

Biological Activity

Fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes.

Technical Data

M. Wt 1368.54
Formula C69H81N11O17S
Sequence LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)
Storage Store at -20°C
CAS Number 1207610-07-8
PubChem ID 91826076
InChI Key PAAUNHNWVWSJKI-CBRXRBRLSA-N
Smiles CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(C(O)=O)c(c1)-c1c-2ccc(=O)cc-2oc2cc(O)ccc12)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670 PMID: 11641394

Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507 PMID: 19754304

Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951 PMID: 14645084


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Citations for LDV FITC

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