Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewP-3FAX-Neu5Ac
Description: Sialic acid analog; sialyltransferase inhibitor
Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity: ≥97% (HPLC)
Biological Activity
Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.
Technical Data
| M. Wt | 551.47 |
| Formula | C22H30FNO14 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 117405-58-0 |
| PubChem ID | 72698605 |
| InChI Key | COXHVKPJIOSDPS-RTEYEINBSA-N |
| Smiles | FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.15 | 100 | |
| ethanol | 27.57 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 551.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.07 mL | 18.13 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID: 22683610
Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID: 25575241
If you know of a relevant reference for P-3FAX-Neu5Ac, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: P-3FAX-Neu5Ac, P-3FAX-Neu5Ac supplier, sialic, acid, analog, sialyltransferases, inhibits, inhibitors, SLeX, Sialyl, Lewis, X, P-selectin, E-selectin, cell, adhesion, metastasis, Other, Transferases, Cell, Adhesion, Molecules, 5760, Tocris Bioscience
Citations for P-3FAX-Neu5Ac
Citations are publications that use Tocris products.
Currently there are no citations for P-3FAX-Neu5Ac. Do you know of a great paper that uses P-3FAX-Neu5Ac from Tocris? Please let us know.
Reviews for P-3FAX-Neu5Ac
There are currently no reviews for this product. Be the first to review P-3FAX-Neu5Ac and earn rewards!
Have you used P-3FAX-Neu5Ac?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Chemogenetics
- Epigenetics
- Fluorescent Imaging
- PROTACs
- Signal Transduction
- Stem Cells