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Description: Sialic acid analog; sialyltransferase inhibitor
Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity: ≥97% (HPLC)

Biological Activity for P-3FAX-Neu5Ac

P-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Technical Data for P-3FAX-Neu5Ac

M. Wt 551.47
Formula C22H30FNO14
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 117405-58-0
PubChem ID 72698605
Smiles FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P-3FAX-Neu5Ac

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 55.15 100
ethanol 27.57 50

Preparing Stock Solutions for P-3FAX-Neu5Ac

The following data is based on the product molecular weight 551.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets for P-3FAX-Neu5Ac

Certificate of Analysis / Product Datasheet
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References for P-3FAX-Neu5Ac

References are publications that support the biological activity of the product.

Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID: 22683610

Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID: 25575241

If you know of a relevant reference for P-3FAX-Neu5Ac, please let us know.

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Keywords: P-3FAX-Neu5Ac, P-3FAX-Neu5Ac supplier, sialic, acid, analog, sialyltransferases, inhibits, inhibitors, SLeX, Sialyl, Lewis, X, P-selectin, E-selectin, cell, adhesion, metastasis, Other, Transferases, Cell, Adhesion, Molecules, 5760, Tocris Bioscience

Citations for P-3FAX-Neu5Ac

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