P-3FAX-Neu5Ac

Pricing Availability Delivery Time Qty
Cat.No. 5760 - P-3FAX-Neu5Ac | C22H30FNO14 | CAS No. 117405-58-0
Description: Sialic acid analog; sialyltransferase inhibitor
Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Technical Data

M. Wt 551.47
Formula C22H30FNO14
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 117405-58-0
PubChem ID 72698605
InChI Key COXHVKPJIOSDPS-RTEYEINBSA-N
Smiles FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.15 100
ethanol 27.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 551.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID: 22683610

Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID: 25575241


If you know of a relevant reference for P-3FAX-Neu5Ac, please let us know.

View Related Products by Product Action

View all Other Transferase Inhibitors

Keywords: P-3FAX-Neu5Ac, supplier, sialic, acid, analog, sialyltransferases, inhibits, inhibitors, SLeX, Sialyl, Lewis, X, P-selectin, E-selectin, cell, adhesion, metastasis, Other, Transferases, Cell, Adhesion, Molecules, Other, Transferases, Tocris Bioscience

Citations for P-3FAX-Neu5Ac

Citations are publications that use Tocris products.

Currently there are no citations for P-3FAX-Neu5Ac. Do you know of a great paper that uses P-3FAX-Neu5Ac from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for P-3FAX-Neu5Ac

Protocols

TODO: Add Protocols