Cilengitide

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Cat.No. 5870 - Cilengitide | cyclo(Arg-Gly-Asp-D-Phe-(NMe)-Val) | CAS No. 188968-51-6
Description: Potent and selective inhibitor of integrins αvβ3 and αvβ5
Alternative Names: EMD121974
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Technical Data

M. Wt 588.66
Formula C27H40N8O7
Sequence RGDFV

(Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclizedl)

Storage Store at -20°C
CAS Number 188968-51-6
PubChem ID 176873
InChI Key AMLYAMJWYAIXIA-VWNVYAMZSA-N
Smiles CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Alghisi et al (2009) The integrin antagonist cilengitide activates αvβ3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 4 e4449 PMID: 19212436

Monnier et al (2008) CYR61 and αvβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 68 7323 PMID: 18794119


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Keywords: Cilengitide, Cilengitide supplier, Potent, selective, inhibitors, inhibits, integrin, αvβ3, αvβ5, alphavbeta3, alphavbeta5, EMD121974, Integrins, Cell, Adhesion, Molecules, 5870, Tocris Bioscience

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