Matrix Metalloproteases

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
2621 ARP 100
Selective inhibitor of MMP-2
2622 ARP 101
Inhibitor of MMP-2
2961 Batimastat
Potent, broad spectrum MMP inhibitor
2632 CL 82198 hydrochloride
Selective inhibitor of MMP-13
3780 CP 471474
Broad spectrum MMP inhibitor
4090 Doxycycline hyclate
Broad-spectrum MMP inhibitor; tetracycline derivative
2983 GM 6001
Broad spectrum MMP inhibitor
2631 Marimastat
Broad spectrum MMP inhibitor
3268 Minocycline hydrochloride
Inhibitor of MMP activity
4902 NSC 405020
Inhibitor of MT1-MMP; antitumor
2628 ONO 4817
Broad spectrum MMP inhibitor
2520 PD 166793
Broad spectrum MMP inhibitor
2916 Ro 32-3555
Potent, collagenase-selective MMP inhibitor
6088 SB 3CT
Selective high affinity MMP2 inhibitor
4775 SD 2590 hydrochloride
Potent MMP inhibitor
4187 UK 356618
Potent and selective MMP-3 inhibitor
2900 UK 370106
Highly selective MMP-3 and MMP-12 inhibitor
4188 UK 383367
Potent and selective BMP-1 (PCP) inhibitor
2633 WAY 170523
Potent and selective inhibitor of MMP-13

Other

Cat No Product Name / Activity
3807 Disulfiram
Inhibits expression of MMP-2 and MMP-9; displays a range of other activities
4604 PTIQ
Potent MMP-3 expression inhibitor; neuroprotective

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules.

24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference:

  1. Collagenases (MMP-1, -8 and -13)
  2. Gelatinases (MMP-2 and MMP-9)
  3. Stromelysins (MMP-3, -10 and -11)
  4. Matrilysin (MMP-7 and MMP-26)
  5. Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25)
  6. Other (MMP-12, -19, -20, -21, -23, -27 and -28)

Following stepwise activation by proteinases, MMP activity is regulated by two major endogenous inhibitors: α2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs 1-4).

MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumor metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondaries at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Matrix Metalloprotease (MMP) Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MMP1 Human MMP1 NM_002421 P03956
Mouse Mmp1a
Mmp1b
NM_032006
NM_032007
Q9EPL5
Q9EPL6
MMP2 Human MMP2 NM_004530 P08253
Mouse Mmp2 NM_008610 P33434
Rat Mmp2 NM_031054 P33436
MMP3 Human MMP3 NM_002422 P08254
Mouse Mmp3 NM_010809 P28862
Rat Mmp3 NM_133523 P03957
MMP7 Human MMP7 NM_002423 P09237
Mouse Mmp7 NM_010810 Q10738
Rat Mmp7 NM_012864 P50280
MMP8 Human MMP8 NM_002424 P22894
Mouse Mmp8 NM_008611 O70138
Rat Mmp8 NM_022221 O88766
MMP9 Human MMP9 NM_004994 P14780
Mouse Mmp9 NM_013599 P41245
Rat Mmp9 NM_031055 P50282
MMP10 Human MMP10 NM_002425 P09238
Mouse Mmp10 NM_019471 O55123
Rat Mmp10 NM_133514 P07152
MMP11 Human MMP11 NM_005940 P24347
Mouse Mmp11 NM_008606 Q02853
Rat Mmp11 NM_012980 Q499S5
MMP12 Human MMP12 NM_002426 P39900
Mouse Mmp12 NM_008605 P34960
Rat Mmp12 NM_053963 Q63341
MMP13 Human MMP13 NM_002427 P45452
Mouse Mmp13 NM_008607 P33435
Rat Mmp13 M60616 P23097
MMP14 Human MMP14 NM_004995 P50281
Mouse Mmp14 NM_008608 P53690
Rat Mmp14 NM_031056 Q10739
MMP15 Human MMP15 NM_002428 P51511
Mouse Mmp15 NM_008609 O54732
MMP16 Human MMP16 NM_005941 P51512
Mouse Mmp16 NM_019724 Q9WTR0
Rat Mmp16 NM_080776 O35548
MMP17 Human MMP17 NM_016155 Q9ULZ9
Mouse Mmp17 NM_011846 Q9R0S3
MMP19 Human MMP19 NM_002429 Q99542
Mouse Mmp19 NM_021412 Q9JHI0
MMP20 Human MMP20 NM_004771 O60882
Mouse Mmp20 NM_013903 P57748
MMP21 Human MMP21 NM_147191 Q8N119
Mouse Mmp21 NM_152944 Q8K3F2
MMP23 Human MMP23B NM_006983 Q9UBR9
Mouse Mmp23 NM_011985 O88676
Rat Mmp23 NM_053606 O88272
MMP24 Human MMP24 NM_006690 Q9Y5R2
Mouse Mmp24 NM_010808 Q9R0S2
Rat Mmp24 NM_031757 Q99PW6
MMP25 Human MMP25 NM_022468 Q9NPA2
Mouse Mmp25 NM_001033339 Q3U435
MMP26 Human MMP26 NM_021801 Q9NRE1
MMP27 Human MMP27 NM_022122 Q9H306
Mouse Mmp27 NM_001030289 NP_001025460
MMP28 Human MMP28 NM_001032278 Q9H239
Mouse Mmp28 NM_080453 NP_536701