BMS 688521

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent inhibitor of the LFA-1/ICAM interaction
Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BMS 688521

BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Compound Libraries for BMS 688521

BMS 688521 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 688521

M. Wt 536.37
Formula C26H19Cl2N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 893397-44-9
PubChem ID 11699447
Smiles CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1C1=CC=C(C=C1)C#N)C1=NC=C(C=C1)C(O)=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 688521

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.64 100

Preparing Stock Solutions for BMS 688521

The following data is based on the product molecular weight 536.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for BMS 688521

References are publications that support the biological activity of the product.

Watterson et al (2010) Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4] J.Med.Chem. 53 3814 PMID: 20405922

If you know of a relevant reference for BMS 688521, please let us know.

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: BMS 688521, BMS 688521 supplier, BMS688521, LFA-1, antagonists, blocker, interaction, inhibitors, inhibits, ICAM1, lymphocyte, function, associated, antigen, intracellular, adhesion, molecule, potent, Integrins, Cell, Adhesion, Molecules, 4970, Tocris Bioscience

1 Citation for BMS 688521

Citations are publications that use Tocris products. Selected citations for BMS 688521 include:

Jing et al (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell Rep 28 2892-2904.e7 PMID: 31509750

Do you know of a great paper that uses BMS 688521 from Tocris? Please let us know.

Reviews for BMS 688521

There are currently no reviews for this product. Be the first to review BMS 688521 and earn rewards!

Have you used BMS 688521?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.