GR 144053 trihydrochloride
Biological Activity
A potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.
Technical Data
| M. Wt | 454.83 |
| Formula | C18H27N5O2.3HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1215333-48-4 |
| PubChem ID | 107895 |
| InChI Key | GFZHNFOGCMEYTA-UHFFFAOYSA-N |
| Smiles | Cl.Cl.Cl.NC(=N)C1=CC=C(C=C1)N1CCN(CC1)C1CCN(CC(O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.48 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 454.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 10.99 mL | 21.99 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Eldred et al (1994) Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37 3882 PMID: 7966149
Matsuno et al (1997) GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 122 1099 PMID: 9480031
Matsuno et al (1999) Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 127 1129 PMID: 10455258
If you know of a relevant reference for GR 144053 trihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GR 144053 trihydrochloride, GR 144053 trihydrochloride supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, antagonists, Antithrombotic, receptor, Adhesion, Molecules, Integrin, Receptors, GR144053, trihydrochloride, Cell, Integrins, 1263, Tocris Bioscience
Citations for GR 144053 trihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for GR 144053 trihydrochloride. Do you know of a great paper that uses GR 144053 trihydrochloride from Tocris? Please let us know.
Reviews for GR 144053 trihydrochloride
There are currently no reviews for this product. Be the first to review GR 144053 trihydrochloride and earn rewards!
Have you used GR 144053 trihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Immunology Product Listing
A collection of over 190 products for immunology research, the guide includes research tools for the study of:
- Chemokine and Cytokine Signaling
- Chemotaxis
- Complement System
- Immune Cell Signaling
- Inflammation
