Focal Adhesion Kinase

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3414 FAK Inhibitor 14
Selective FAK inhibitor
4278 PF 431396
Dual FAK/PYK2 inhibitor
3239 PF 573228
Potent and selective FAK inhibitor
4498 Y 11
Potent and selective FAK inhibitor

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. Therefore, FAK plays a key role in cellular migration and motility.

FAK has 3 functional domains: a focal adhesion targeting domain (FAT), a catalytic domain and a FERM domain, which mediates interactions with the cytoplasmic domains of integrins and growth factor receptors. FAK has multiple phosphorylation sites that are required for binding to adaptor proteins containing SH2 domains (e.g. Src and SH3 domains (e.g. CAS, GRAF)). Key amongst these phosphorylation sites is Tyr397, which is important for the interaction of FAK with downstream signaling molecules such as PI 3-K, PLCγ and Rho kinase.

Overexpression of FAK has been associated with several types of cancer.

Literature for Focal Adhesion Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Focal Adhesion Kinase Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PTK2 NM_005607 Q05397
Mouse Ptk2 NM_007982 P34152
Rat Ptk2 NM_013081 Q62899