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Submit ReviewCyclo(-RGDfK) New
Description: Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
Purity: ≥95% (HPLC)
Biological Activity for Cyclo(-RGDfK)
Cyclo(-RGDfK) is a cyclic peptide, potent integrin inhibitor (IC50 values are 2.3 and 55 nM for αvβ3 and αvβ6, respectively). Cyclo(-RGDfK) improves human pluripotent stem cell (hPSC) adhesion and proliferaton on 3D cell culture synthetic surfaces. Can also be used to target fluorophores and cargo to cancer cells as αvβ3 integrin is upregulated on cancer cells.
Technical Data for Cyclo(-RGDfK)
| M. Wt | 603.68 |
| Formula | C27H41N9O7 |
| Sequence |
RGDFK (Modifications: Lactam bridge: Arg-1 to Lys-5, Phe-4:D-Phe) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 161552-03-0 |
| PubChem ID | 10196873 |
| InChI Key | NVHPXYIRNJFKTE-HAGHYFMRSA-N |
| Smiles | O=C(NCC(N[C@@H](CC(O)=O)C(N[C@H](CC1=CC=CC=C1)C(N[C@H]2CCCCN)=O)=O)=O)[C@H](CCCNC(N)=N)NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cyclo(-RGDfK)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Cyclo(-RGDfK)
References for Cyclo(-RGDfK)
References are publications that support the biological activity of the product.
Yu et al (2017) Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death Dis. 8 e2737 PMID: 28383553
Lambshead et al (2018) Long-term maintenance of human pluripotent stem cells on cRGDfK-presenting synthetic surfaces. Sci.Rep. 8 701 PMID: 29335618
Kapp et al (2017) A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci Rep 7 39805 PMID: 28074920
Gamage et al (2021) Comparison of cRGDfK peptide probes with appended shielded heptamethine cyanine dye (s775z) for near infrared fluorescence imaging of cancer. ACS Omega 6 30130 PMID: 34778684
If you know of a relevant reference for Cyclo(-RGDfK), please let us know.
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Keywords: Cyclo(-RGDfK), Cyclo(-RGDfK) supplier, peptide, integrin, binding, cell, adhesion, 3D, culture, stem, cells, hPSC, proliferation, potent, inhibitors, inhibits, inhibition, biomaterials, Integrins, Cell, Adhesion, Molecules, Stem, Proliferation, 8917, Tocris Bioscience
Citations for Cyclo(-RGDfK)
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