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BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).
Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.
High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.
BOP is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 537.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.86 mL||9.3 mL||18.6 mL|
|5 mM||0.37 mL||1.86 mL||3.72 mL|
|10 mM||0.19 mL||0.93 mL||1.86 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056
Pepinsky et al (2002) Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 41 7125 PMID: 12033947
Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966
If you know of a relevant reference for BOP, please let us know.
Keywords: BOP, BOP supplier, Dual, α9β/1α4β1, integrin, inhibitors, inhibits, rapidly, mobilizes, HSC, progenitors, hematopoietic, haematopoietic, stem, cells, Integrins, Cell, Adhesion, Molecules, Stem, Signaling, Hematopoietic, Cells, 6047, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for BOP include:
Upadhaya et al (2020) Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche Cell Stem Cell 27 336 PMID: 32589864
Do you know of a great paper that uses BOP from Tocris? Please let us know.
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