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Cat.No. 6047 - BOP | C25H28N3O7SNa | CAS No. 1947348-42-6
Description: Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
Chemical Name: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity: ≥98% (HPLC)

Biological Activity

Dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Technical Data

M. Wt 537.56
Formula C25H28N3O7SNa
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1947348-42-6
PubChem ID 10301396
Smiles O=C([C@@H](NC([C@@H]1CCCN1S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)OC(N4CCCC4)=O)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.76 100
ethanol 53.76 100
water 53.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 537.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.3 mL 18.6 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vi Org.Biomol.Chem. 12 965 PMID: 24363056

Pepinsky et al (2002) Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 41 7125 PMID: 12033947

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966

If you know of a relevant reference for BOP, please let us know.

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Keywords: BOP, supplier, Dual, α9β/1α4β1, integrin, inhibitors, inhibits, rapidly, mobilizes, HSC, progenitors, hematopoietic, stem, cell, Integrins, Cell, Adhesion, Molecules, Stem, Cell, Signaling, Integrins, Tocris Bioscience

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