TCS 2314

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Cat.No. 3900 - TCS 2314 | C28H34N4O6 | CAS No. 317353-73-4
Description: α4β1 (VLA-4) antagonist
Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM). Blocks the activation of inflammatory cells.

Compound Libraries

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Technical Data

M. Wt 522.59
Formula C28H34N4O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 317353-73-4
PubChem ID 11226207
InChI Key ITXAAOWFOURIHK-DEOSSOPVSA-N
Smiles O=C(N2CCOC[C@H]2[C@@](N3CCC(CC(O)=O)CC3)=O)CC1=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.26 100
ethanol 26.13 50

Preparing Stock Solutions

The following data is based on the product molecular weight 522.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.57 mL 19.14 mL
5 mM 0.38 mL 1.91 mL 3.83 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References

References are publications that support the biological activity of the product.

Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440


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Citations for TCS 2314

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Literature in this Area

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