Pricing Availability   Qty
Description: Disrupts MTDH and SND1 interaction, enhances immune surveillance
Chemical Name: 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide
Purity: ≥98% (HPLC)

Biological Activity for C26-A6

C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC50 = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.

Technical Data for C26-A6

M. Wt 352.79
Formula C14H13ClN4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1341030-00-9
PubChem ID 87054166
Smiles COC1=C(S(=O)(NC2=CC=CN3N=C(N=C23)C)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C26-A6

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.28 100

Preparing Stock Solutions for C26-A6

The following data is based on the product molecular weight 352.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for C26-A6

References are publications that support the biological activity of the product.

Shen et al (2022) Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat.Cancer 3 43 PMID: 35121987

Shen et al (2022) Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat.Cancer 3 60 PMID: 35121988

If you know of a relevant reference for C26-A6, please let us know.

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