C26-A6

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Cat.No. 7692 - C26-A6 | C14H13ClN4O3S | CAS No. 1341030-00-9
Description: Disrupts MTDH and SND1 interaction, enhances immune surveillance
Chemical Name: 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for C26-A6

C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC50 = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.

Technical Data for C26-A6

M. Wt 352.79
Formula C14H13ClN4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1341030-00-9
PubChem ID 87054166
InChI Key HLRMNXITZQAUIH-UHFFFAOYSA-N
Smiles COC1=C(S(=O)(NC2=CC=CN3N=C(N=C23)C)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C26-A6

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.28 100

Preparing Stock Solutions for C26-A6

The following data is based on the product molecular weight 352.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for C26-A6

References are publications that support the biological activity of the product.

Shen et al (2022) Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat.Cancer 3 43 PMID: 35121987

Shen et al (2022) Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat.Cancer 3 60 PMID: 35121988


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Keywords: C26-A6, C26-A6 supplier, C26A6, Inhibitors, inhibits, protein, interaction, MTDH, SND1, triple-negative, breast, cancer, TNBC, tumor, antigen, presentation, metastasis, enhances, anti-programmed, cell, death, 1, therapy, chemotherapy, sensitivity, Cell, Adhesion, Molecules, 7692, Tocris Bioscience

Citations for C26-A6

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis