Src Kinases

Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3914 A 419259 trihydrochloride
Inhibitor of Src family kinases
3963 AZM 475271
Src tyrosine kinase inhibitor
4361 Bosutinib
Dual Src-Abl inhibitor; antiproliferative
1936 Damnacanthal
Potent, selective p56lck inhibitor; also LIMK1/2 inhibitor
1629 Herbimycin A
Src family kinase inhibitor. Also Hsp90 inhibitor
4660 KB SRC 4
Potent and selective c-Src inhibitor
1331 Lavendustin A
EGFR, p60c-src inhibitor
5592 LCB 03-0110 dihydrochloride
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
2265 Lyn peptide inhibitor
Inhibits Lyn activation via hematopoietin βc receptor; cell-permeable
2877 MNS
Selective inhibitor of Src and Syk
3063 1-Naphthyl PP1
Src family kinase inhibitor; also inhibits c-Abl
6073 P21d hydrochloride
Potent and selective Brk inhibitor
3785 PD 166285 dihydrochloride
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
4965 PD 180970
p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT
1554 Piceatannol
p56lck and Syk kinase inhibitor
1397 PP 1
Potent, selective Src family kinase inhibitor
1407 PP 2
Potent, selective Src family kinase inhibitor
2794 PP 3
Negative control for PP 2 (Cat. No. 1407)
1923 pp60 c-src (521-533) (phosphorylated)
Inhibits tyrosine kinase activity of pp60c-src and pp60v-src
3642 Src I1
Dual site Src kinase inhibitor
3567 TC-S 7003
Potent Lck inhibitor
5579 Tilfrinib
Potent and selective breast tumor kinase (Brk) inhibitor
5413 WH-4-023
Potent and selective Lck and Src inhibitor; also inhibits SIK

Activators

Cat No Product Name / Activity
4582 MLR 1023
Selective allosteric activator of Lyn kinase

Ligands

Cat No Product Name / Activity
1930 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide
Phosphopeptide ligand for src SH2 domain
1927 N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
Phosphopeptide ligand for src SH2 domain
1935 Caffeic acid-pYEEIE
Phosphopeptide ligand for src SH2 domain

Other

Cat No Product Name / Activity
4763 Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; targets the proto-oncogene SRC

Related Targets

    Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains.

    c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of Tyr530 is required to switch the kinase from the inactive 'closed' formation to the active 'open' formation. c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases (e.g. SHP1), by binding to adaptor proteins (e.g. Cbp) and by proteasomal degradation. Src kinases are key upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important roles in cell proliferation, migration and survival.

    Literature for Src Kinases

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Src Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Src Human SRC NM_198291 P12931
    Mouse Src NM_009271 P05480
    Rat Src NM_031977 Q9WUD9
    Fyn Human FYN NM_153048 P06241
    Mouse Fyn NM_001122893 P39688
    Rat Fyn NM_012755 Q62844
    Yes Human YES1 NM_005433 P07947
    Mouse YES1 NM_009535 Q04736
    Rat Yes1 NM_033298 P97540
    Lck Human LCK NM_005356 Q9NYT8
    Mouse Lck NM_010693 P06240
    Rat Lck NM_001100709 Q01621
    Lyn Human LYN NM_001111097 P07948
    Mouse Lyn NM_001111096 P25911
    Rat Lyn NM_030857 Q07014
    Hck Human HCK NM_002110 Q9NUA4
    Mouse Hck NM_010407 P08103
    Rat Hck NM_013185 P50545
    Fgr Human FGR NM_005248 P09769
    Mouse Fgr NM_010208 P14234
    Rat Fgr NM_024145 Q6P6U0
    Blk Human BLK NM_001715 P51451
    Mouse Blk NM_007549 P16277
    Rat Blk NM_001025751 Q4KM97