BIO 1211

Pricing Availability Delivery Time Qty
Cat.No. 3910 - BIO 1211 | MPUPA-Leu-Asp-Val-Pro | CAS No. 187735-94-0
Description: Selective α4β1 (VLA-4) inhibitor
Citations (2)

Biological Activity

Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).

Technical Data

M. Wt 708.8
Formula C36H48N6O9
Storage Store at -20°C
CAS Number 187735-94-0
PubChem ID 9961766
Smiles O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 0.2M PBS

Preparing Stock Solutions

The following data is based on the product molecular weight 708.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.05 mL 14.11 mL
5 mM 0.28 mL 1.41 mL 2.82 mL
10 mM 0.14 mL 0.71 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167 PMID: 10224072

Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920 PMID: 10072689

Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440

If you know of a relevant reference for BIO 1211, please let us know.

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: BIO 1211, supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Integrins, Cell, Adhesion, Molecules, Integrins, Tocris Bioscience

2 Citations for BIO 1211

Citations are publications that use Tocris products. Selected citations for BIO 1211 include:

Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738 PMID: 24695572

Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352 PMID: 25830878

Do you know of a great paper that uses BIO 1211 from Tocris? If so please let us know.

Reviews for BIO 1211

There are currently no reviews for this product. Be the first to review BIO 1211 and earn rewards!

Have you used BIO 1211?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation