Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in 0.2M PBS|
Preparing Stock Solutions
The following data is based on the product molecular weight 708.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.41 mL||7.05 mL||14.11 mL|
|5 mM||0.28 mL||1.41 mL||2.82 mL|
|10 mM||0.14 mL||0.71 mL||1.41 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167 PMID: 10224072
Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920 PMID: 10072689
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440
If you know of a relevant reference for BIO 1211, please let us know.
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Keywords: BIO 1211, supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Integrins, Cell, Adhesion, Molecules, Integrins, Tocris Bioscience
2 Citations for BIO 1211
Citations are publications that use Tocris products. Selected citations for BIO 1211 include:
Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738 PMID: 24695572
Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352 PMID: 25830878
Do you know of a great paper that uses BIO 1211 from Tocris? If so please let us know.
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