BIO 1211

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Cat.No. 3910 - BIO 1211 | MPUPA-Leu-Asp-Val-Pro | CAS No. 187735-94-0
Description: Selective α4β1 (VLA-4) inhibitor
Datasheet
Citations (2)
Literature

Biological Activity

Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).

Technical Data

M. Wt 708.8
Formula C36H48N6O9
Sequence MPUPA-LDVP
Storage Store at -20°C
CAS Number 187735-94-0
PubChem ID 9961766
InChI Key NVVGCQABIHSJSQ-KFZSMJGVSA-N
Smiles O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 0.2M PBS

Preparing Stock Solutions

The following data is based on the product molecular weight 708.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.05 mL 14.11 mL
5 mM 0.28 mL 1.41 mL 2.82 mL
10 mM 0.14 mL 0.71 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167 PMID: 10224072

Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920 PMID: 10072689

Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440


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Keywords: BIO 1211, supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Integrins, Tocris Bioscience

2 Citations for BIO 1211

Citations are publications that use Tocris products. Selected citations for BIO 1211 include:

Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352 PMID: 25830878

Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738 PMID: 24695572


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Literature in this Area

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for BIO 1211

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