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Autophagy Activators

Cat. No. Product Name / Activity
3336 A 769662
Autophagy activator; potent AMPK activator
1234 A23187, free acid
Causes ER stress; can be used to induce autophagy in mammalian cells
7680 ABT 263
Induces autophagy; Bcl-2 family inhibitor
4095 Amiodarone hydrochloride
Causes mitochondrial fragmentation and cell death; stimulates autophagy
7699 AUTAC4
Autophagy-targeting Degrader; targets dysfuntional mitochondria for degradation; ligand of the translocator protein (TSPO)
1231 Brefeldin A
Causes ER stress; induces autophagy in mammalian cells
4098 Carbamazepine
Induces autophagy by inhibiting inositol synthesis; Inhibits neuronal NaV channels
0690 Clonidine hydrochloride
α2 agonist and I1 ligand; thought to enhance autophagy
1126 Dexamethasone
Anti-inflammatory glucocorticoid; also induces autophagy in ALL cell lines
3093 Dorsomorphin dihydrochloride
Induces autophagy via an AMPK inhibition-independent mechanism
7474 EN6
Activator of autophagy; inactivates mTORC1 signaling
6188 Everolimus
Autophagy activator; mTOR inhibitor
4808 FK 866 hydrochloride
Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy
0741 GF 109203X
Protein kinase C inhibitor
0681 L-690,330
Inositol monophosphatase inhibitor; induces autophagy independently of mTOR inhibition
6617 LYN 1604 dihydrochloride
Induces autophagy; ULK1 agonist
2864 Metformin hydrochloride
Activator of LKB1/AMPK; activates autophagy
1391 NF 449
Highly selective P2X1 antagonist; Gsα-selective antagonist
4079 Niclosamide
STAT3 inhibitor; also inhibits mTORC1 signaling. Stimulates autophagy in vitro
0600 Nimodipine
Induces autophagy; Ca2+ channel blocker (L-type)
0601 Nitrendipine
Induces autophagy; Ca2+ channel blocker (L-type)
6087 Perifosine
PKB/Akt inhibitor; induces autophagy
2930 PI 103 hydrochloride
Inhibitor of PI 3-kinase, mTOR and DNA-PK
1267 Pifithrin-α hydrobromide
p53 inhibitor
1292 Rapamycin
mTOR inhibitor; induces autophagy
1418 Resveratrol
Autophagy activator; also cyclooxygenase inhibitor
0695 Retinoic acid
Autophagy activator; also endogenous retinoic acid receptor agonist
0790 Rilmenidine hemifumarate
α2 agonist and I1 ligand; thought to enhance autophagy
1610 Rottlerin
Stimulates autophagy
4652 SAHA
Autophagy activator; also Class I and II HDAC inhibitor
4297 SMER 28
Positive regulator of autophagy
7558 SRT 1720
Induces autophagy; SIRT1 activator
2706 Temozolomide
DNA-methylating antitumor agent; also induces autophagy
5264 Temsirolimus
Autophagy activator; mTOR inhibitor
1138 Thapsigargin
Causes ER stress; can be used to induce autophagy in mammalian cells
4247 Torin 1
Potent and selective mTOR inhibitor; induces autophagy in HeLa cells
4248 Torin 2
Autophagy activator; also potent and selective mTOR inhibitor
1406 Trichostatin A
Autophagy activator; potent histone deacetylase inhibitor
3516 Tunicamycin
Causes ER stress; can be used to induce autophagy
2815 Valproic acid, sodium salt
Reduces inositol levels; induces autophagy
0654 Verapamil hydrochloride
Ca2+ channel blocker (L-type); induces autophagy
7878 XIE62-1004
Inducer of autophagy via interaction of p62 and LC3

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