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Biological Activity for EN6
EN6 is an activator of lysosomal vacuolar H+ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.
Technical Data for EN6
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EN6
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for EN6
The following data is based on the product molecular weight 368.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||27.15 mL||135.74 mL||271.49 mL|
|0.5 mM||5.43 mL||27.15 mL||54.3 mL|
|1 mM||2.71 mL||13.57 mL||27.15 mL|
|5 mM||0.54 mL||2.71 mL||5.43 mL|
References for EN6
References are publications that support the biological activity of the product.
Chung et al (2019) Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat.Chem.Biol. 15 776 PMID: 31285595
Su et al (2021) Role and dynamics of vacuolar pH during cell-in-cell mediated death. Cell Death Dis. 12 119 PMID: 33483474
If you know of a relevant reference for EN6, please let us know.
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Keywords: EN6, EN6 supplier, EN6, activators, activates, autophagy, mTORC1signaling, lysosomes, lysosomal, vacuolar, H+, ATPases, entosis, v-ATPase, mTORC1, Autophagy, H+-ATPase, 7474, Tocris Bioscience
Citations for EN6
Citations are publications that use Tocris products.
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