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Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 392.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.55 mL||12.74 mL||25.48 mL|
|5 mM||0.51 mL||2.55 mL||5.1 mL|
|10 mM||0.25 mL||1.27 mL||2.55 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909 PMID: 10614771
Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45 PMID: 20648425
Teixeira et al (1996) Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317 PMID: 8735633
Merck Index 12 2986
Laane et al (2009) Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018 PMID: 19390558
Huch et al (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160 299 PMID: 25533785
Deng et al (2014) The effect of dexamethasone on lentiviral vector infection is associated with importin α. Biomed.Rep. 2 137 PMID: 24649085
Seregin et al (2009) Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol.Ther. 17 685 PMID: 19174760
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Keywords: Dexamethasone, Dexamethasone supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, liver, organoids, viral, transduction, enhancers, Glucocorticoid, Receptor, Autophagy, Mesenchymal, Stem, Cells, NF-kB/IkB, Organoids, Viral, Transduction, Enhancers, 1126, Tocris Bioscience
8 Citations for Dexamethasone
Citations are publications that use Tocris products. Selected citations for Dexamethasone include:
Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630
Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390 PMID: 24548290
Segal et al (2019) Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun 10 3350 PMID: 31350390
Peng et al (2018) Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell 175 1607 PMID: 30500539
Sampaziotis et al (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc 12 814 PMID: 28333915
Ibrahim et al (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci 12 453 PMID: 30524245
Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res.Bull. 124 222 PMID: 27208730
Carbone et al (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. J Neurosci 60 42613 PMID: 22080156
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.