Dexamethasone

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Description: Anti-inflammatory glucocorticoid
Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (2)
Literature (1)

Biological Activity for Dexamethasone

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Dexamethasone

Dexamethasone is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Dexamethasone

M. Wt 392.47
Formula C22H29FO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50-02-2
PubChem ID 9830630
InChI Key UREBDLICKHMUKA-WNYCSEIESA-N
Smiles O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dexamethasone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.25 100

Preparing Stock Solutions for Dexamethasone

The following data is based on the product molecular weight 392.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for Dexamethasone

Certificate of Analysis / Product Datasheet
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References for Dexamethasone

References are publications that support the biological activity of the product.

Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909 PMID: 10614771

Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45 PMID: 20648425

Teixeira et al (1996) Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317 PMID: 8735633

Merck Index 12 2986

Laane et al (2009) Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018 PMID: 19390558

Huch et al (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160 299 PMID: 25533785

Deng et al (2014) The effect of dexamethasone on lentiviral vector infection is associated with importin α. Biomed.Rep. 2 137 PMID: 24649085

Seregin et al (2009) Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol.Ther. 17 685 PMID: 19174760


If you know of a relevant reference for Dexamethasone, please let us know.

Keywords: Dexamethasone, Dexamethasone supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, liver, organoids, viral, transduction, enhancers, Glucocorticoid, Receptor, Autophagy, Mesenchymal, Stem, Cells, NF-kB/IkB, Organoids, Viral, Transduction, Enhancers, 1126, Tocris Bioscience

8 Citations for Dexamethasone

Citations are publications that use Tocris products. Selected citations for Dexamethasone include:

Peng et al (2018) Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell 175 1607 PMID: 30500539

Ibrahim et al (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci 12 453 PMID: 30524245

Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res.Bull. 124 222 PMID: 27208730

Carbone et al (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. J Neurosci 60 42613 PMID: 22080156


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Reviews for Dexamethasone

Average Rating: 5 (Based on 2 Reviews.)

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Dexamethasone used in HUDEP-2 cell culture.
By Anonymous on 12/11/2023
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HUDEP-2

Dexamethasone (Cat. No. 1126) was used in HUDEP-2 (erythroid progenitor cells) cell culture media. Image shows culture of the erythroid progenitor cell line HUDEP-2.

review image

Great anti-inflammatory drug.
By Luiz Alexandre Magno on 02/17/2022
Assay Type: In Vivo
Species: Mouse

I used this drug to decrease the levels of IL-1, which is a proinflammatory cytokine. By doing this, we can explore the outcome of signalling pathways that can cause brain disease

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.