Dexamethasone

Pricing Availability   Qty
Cat.No. 1126 - Dexamethasone | C22H29FO5 | CAS No. 50-02-2
Description: Anti-inflammatory glucocorticoid
Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (5)

Biological Activity

Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries

Dexamethasone is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 392.47
Formula C22H29FO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50-02-2
PubChem ID 9830630
InChI Key UREBDLICKHMUKA-LSGPFJJXSA-N
Smiles O=C1C=CC2(C)C(CC[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@@](O)4C(CO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909 PMID: 10614771

Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45 PMID: 20648425

Teixeira et al (1996) Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317 PMID: 8735633

Merck Index 12 2986

Laane et al (2009) Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018 PMID: 19390558

Huch et al (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160 299 PMID: 25533785


If you know of a relevant reference for Dexamethasone, please let us know.

Keywords: Dexamethasone, Dexamethasone supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, liver, organoids, Glucocorticoid, Receptor, Autophagy, Mesenchymal, Stem, Cells, COVID-19, NF-kB/IkB, Organoids, 1126, Tocris Bioscience

8 Citations for Dexamethasone

Citations are publications that use Tocris products. Selected citations for Dexamethasone include:

Segal et al (2019) Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun 10 3350 PMID: 31350390

Sampaziotis et al (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc 12 814 PMID: 28333915

Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630

Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390 PMID: 24548290


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Reviews for Dexamethasone

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Literature in this Area

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