mTOR

mTOR (mechanistic Target Of Rapamycin, mammalian Target Of Rapamycin) plays a key role in coordinating cell signaling pathways. mTOR is a large (>280kD), multidomain protein with a kinase domain and a FKBP12 binding domain.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
5615 AZD 3147
Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
3271 Compound 401
Selective mTOR and DNA-PK inhibitor
5955 eCF 309
Potent mTOR inhibitor
4702 ETP 45658
mTOR inhibitor; also inhibits PI 3-K and DNA-PK
6188 Everolimus
mTOR inhibitor;immunosuppressant
3725 KU 0063794
Selective mTOR inhibitor
4079 Niclosamide
STAT3 inhibitor; also inhibits mTORC1 signaling
4820 PF 04691502
Dual PI 3-K/mTOR inhibitor
4823 PF 05212384
Potent and selective dual PI 3-kinase/mTOR inhibitor
2930 PI 103 hydrochloride
Inhibitor of mTOR, PI 3-kinase and DNA-PK
3894 PP 121
Dual kinase inhibitor; inhibits PI 3K family kinases
4257 PP 242
Dual mTORC1/mTORC2 inhibitor
1292 Rapamycin
mTOR inhibitor; immunosuppressant
6036 STK16-IN-1
mTOR kinase inhibitor; also inhibits PI 3Kδ, PI 3Kγ and STK16 kinases
5264 Temsirolimus
mTOR inhibitor; antitumor
4247 Torin 1
Potent and selective mTOR inhibitor
4248 Torin 2
Potent and selective mTOR inhibitor
4282 WYE 687 dihydrochloride
Potent and selective mTOR inhibitor
4893 XL 388
Potent and selective mTOR inhibitor; antitumor

mTOR (mechanistic Target Of Rapamycin, mammalian Target Of Rapamycin aka FRAP, FK506 binding protein 12 (FKBP12)-rapamycin associated protein 1) plays a key role in coordinating the signals for a number of pathways, including insulin signaling, nutrient sensing and mitogenic signaling. mTOR is a large (>280kD), multidomain protein that includes a kinase domain and a FKBP12 binding domain. Rapamycin binds to FKBP12 and then complexes with mTOR to inhibit the enzyme.

The PI 3-K pathway regulates mTOR via the tuberous sclerosis proteins, TSC1 and TSC2. These proteins activate the small GTPase Rheb, that in turn binds and activates the kinase domain of mTOR. In cells, mTOR exists as two large complexes: mTORC1 and mTORC2. mTORC1 includes several proteins, including the regulatory protein Raptor and mTORC2 includes the regulatory protein Rictor. Only mTORC1 is rapamycin sensitive. Upstream signals regulating mTORC1 include growth factors, and glucose and oxygen levels. The most widely known phosphorylation targets of mTORC1 are the key components of the protein translation machinery, 4E-BP and p70 S6 kinase 1(S6K1). A key role of mTORC2 is actin organization, although mTORC2 can phosphorylate and activate Akt. Serum glucocorticoid-induced protein kinase 1 (SGK1) has been recently identified as an mTORC2 substrate. mTORC2 is not as sensitive to nutrient levels as mTORC1, and is insensitive to rapamycin.

mTORC1 is a sensor of nutrient and growth factor levels. Consequently, it has been linked to autophagy and other metabolic pathways. mTORC1 inhibits autophagy in the presence of nutrients; under conditions such as those resulting from starvation, infection, or oxidative stress, mTORC1 is inhibited and autophagy is triggered. AMPK also inhibits mTORC1 in response to glucose deprivation. mTORC1 has also been associated with glycolysis, and sterol and lipid biosynthesis. Its regulation of SREBP-1 (sterol regulatory element binding protein 1) and HIF (hypoxia-inducible factor) is suggestive of a role for mTORC1 in cellular mechanisms balancing nutrient sensing with carbohydrate and lipid metabolism.

Literature for mTOR

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for mTOR

mTOR

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.

mTOR Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human MTOR NM_004958 P42345
Mouse Mtor NM_020009 Q9JLN9
Rat Mtor NM_019906 P42346