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Cat.No. 0681 - L-690,330 | C8H12O8P2 | CAS No. 142523-38-4
Description: Inositol monophosphatase inhibitor
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Citations (6)

Biological Activity

A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 298.13
Formula C8H12O8P2
Storage Store at RT
CAS Number 142523-38-4
PubChem ID 132449
Smiles CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.81 100mM with gentle warming
ethanol 14.91 50mM with gentle warming
water 29.81 100mM with gentle warming
phosphate buffered saline 29.81 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 298.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.77 mL 33.54 mL
5 mM 0.67 mL 3.35 mL 6.71 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652 PMID: 8380439

Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513

Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101 PMID: 16186256

If you know of a relevant reference for L-690,330, please let us know.

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Keywords: L-690,330, supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330, Inositol, Lipids, Inositol, Phosphatases, Autophagy, Inositol, Phosphatases, Tocris Bioscience

6 Citations for L-690,330

Citations are publications that use Tocris products. Selected citations for L-690,330 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun 81 4261 PMID: 24002062

Meyer et al (2011) Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol 162 1410 PMID: 21138421

Sarkar et al (2008) A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. J Cell Biol 17 170 PMID: 17921520

Criollo et al (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14 1029 PMID: 17256008

Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. Infect Immun 170 1101 PMID: 16186256

Westfall et al (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol 162 889 PMID: 12952939

Do you know of a great paper that uses L-690,330 from Tocris? If so please let us know.

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