Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Inositol monophosphatase inhibitor
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Citations (6)

Biological Activity for L-690,330

L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-690,330

M. Wt 298.13
Formula C8H12O8P2
Storage Store at RT
CAS Number 142523-38-4
PubChem ID 132449
Smiles CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-690,330

Solvent Max Conc. mg/mL Max Conc. mM
water 5.96 20

Preparing Stock Solutions for L-690,330

The following data is based on the product molecular weight 298.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 16.77 mL 83.86 mL 167.71 mL
1 mM 3.35 mL 16.77 mL 33.54 mL
2 mM 1.68 mL 8.39 mL 16.77 mL
10 mM 0.34 mL 1.68 mL 3.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for L-690,330

Certificate of Analysis / Product Datasheet
Select another batch:

References for L-690,330

References are publications that support the biological activity of the product.

Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652 PMID: 8380439

Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513

Sarkar et al (2005) Li induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101 PMID: 16186256

If you know of a relevant reference for L-690,330, please let us know.

View Related Products by Product Action

View all Inositol Phosphatase Inhibitors

Keywords: L-690,330, L-690,330 supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330, Autophagy, 0681, Tocris Bioscience

6 Citations for L-690,330

Citations are publications that use Tocris products. Selected citations for L-690,330 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun 81 4261 PMID: 24002062

Meyer et al (2011) Inhibition of inositol monophosphatase by Li chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol 162 1410 PMID: 21138421

Sarkar et al (2008) A rational mechanism for combination treatment of Huntington's disease using Li and rapamycin. J Cell Biol 17 170 PMID: 17921520

Westfall et al (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol 162 889 PMID: 12952939

Sarkar et al (2005) Li induces autophagy by inhibiting inositol monophosphatase. Infect Immun 170 1101 PMID: 16186256

Criollo et al (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14 1029 PMID: 17256008

Do you know of a great paper that uses L-690,330 from Tocris? Please let us know.

Reviews for L-690,330

There are currently no reviews for this product. Be the first to review L-690,330 and earn rewards!

Have you used L-690,330?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review