Nimodipine

Pricing Availability Delivery Time Qty
Cat.No. 0600 - Nimodipine | C21H26N2O7 | CAS No. 66085-59-4
Description: Ca2+ channel blocker (L-type)
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (17)
Reviews
Literature

Biological Activity

L-type Ca2+ channel blocker.

Technical Data

M. Wt 418.45
Formula C21H26N2O7
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 66085-59-4
PubChem ID 4497
InChI Key UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Smiles COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.84 100
ethanol 4.18 10

Preparing Stock Solutions

The following data is based on the product molecular weight 418.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.9 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Batuecas et al (1998) Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 350 141 PMID: 9696401

Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309 PMID: 2203191

Kappelle et al (1994) Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol. 111 887 PMID: 8019766

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513


If you know of a relevant reference for Nimodipine, please let us know.

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Keywords: Nimodipine, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Calcium, Channels, Autophagy, Voltage-gated, Calcium, Channels, Tocris Bioscience

17 Citations for Nimodipine

Citations are publications that use Tocris products. Selected citations for Nimodipine include:

Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863

Gan and Silverman (2015) Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons. PLoS One 26 1058 PMID: 25609087

Ciani et al (2015) Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. PLoS One 6 8302 PMID: 26400647

Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. Front Cell Neurosci 10 e0117555 PMID: 25689857

Robinson et al (2015) Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. EMBO J 9 404 PMID: 26500501

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. Br J Pharmacol 33 11206 PMID: 23825423

Jurgens et al (2012) Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One 7 e45717 PMID: 23029198

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757 PMID: 22302815

Colgan et al (2012) Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites. J Neurosci 32 15737 PMID: 23136413

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Neurosci 31 2937 PMID: 22531784

Dilger et al (2011) Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse. J Physiol 589 919 PMID: 21173075

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126

Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958 PMID: 20601948

Bender et al (2006) Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci 26 4166 PMID: 16624937

Haeberle et al (2004) Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A 101 14503 PMID: 15448211

Haeberle et al Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Mol Biol Cell 3 e1750 PMID: 18454189

Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196


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