Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.
Deuterated analog also available.
Metformin hydrochloride is also offered as part of the Tocriscreen Plus, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 165.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.04 mL||30.19 mL||60.38 mL|
|5 mM||1.21 mL||6.04 mL||12.08 mL|
|10 mM||0.6 mL||3.02 mL||6.04 mL|
|50 mM||0.12 mL||0.6 mL||1.21 mL|
References are publications that support the biological activity of the product.
Shaw et al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642 PMID: 16308421
Towler and Hardie (2007) AMP-activated protein kinase in metabolic control and insulin signalling. Circ.Res. 100 328 PMID: 17307971
Hirsch et al (2013) Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc.Natl.Acad.Sci.USA 110 972 PMID: 23277563
Wang et al (2012) Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 11 23 PMID: 22770240
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
If you know of a relevant reference for Metformin hydrochloride, please let us know.
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Keywords: Metformin hydrochloride, Metformin hydrochloride supplier, activators, LKB1/AMPK, antidiabetic, agent, AMP-Activated, Protein, Kinases, Enzyme, Substrates, /, Activators, AMPK, Neural, Stem, Cells, Autophagy, 2864, Tocris Bioscience
11 Citations for Metformin hydrochloride
Citations are publications that use Tocris products. Selected citations for Metformin hydrochloride include:
Massey (2017) Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage. Sci Rep 7 40778 PMID: 28106079
Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Nat Commun 9 4709 PMID: 26316709
Naka et al (2015) Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. BMC Cancer 6 8039 PMID: 26289811
Li et al (2016) Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell 7 478 PMID: 27271327
Valente et al (2014) OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med 70 117 PMID: 24561578
Abdou et al (2014) A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol 34 4257 PMID: 25225331
Edris et al (2012) Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. Sarcoma 2012 805614 PMID: 22919280
Xintaropoulou et al (2015) A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget 6 25677 PMID: 26259240
Yan et al (2015) Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat 1 5 PMID: 26120598
Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500 PMID: 25751140
Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. PLoS One 13 327 PMID: 23819460
Do you know of a great paper that uses Metformin hydrochloride from Tocris? Please let us know.
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Used in brain slices to activate AMPK, but no effect on cell dynamic was found. No positive control was used though, so unsure if lack of effect is due to drug...
Literature in this Area
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