Verapamil hydrochloride

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Description: CaV1.x blocker
Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (11)
Reviews (1)

Biological Activity for Verapamil hydrochloride

Verapamil hydrochloride is an L-type calcium channel blocker, anti-arrythmic, vasodilator and adrenergic antagonist. Induces autophagy by modulating cellular metabolism. Verapamil is a P-glycoprotein inhibitor and can reverse resistance to glucocorticoids and cancer treatments. Verapamil has been identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Verapamil hydrochloride

M. Wt 491.07
Formula C27H38N2O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 152-11-4
PubChem ID 62969
InChI Key DOQPXTMNIUCOSY-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(C=C1OC)C(CCCN(C)CCC1=CC(OC)=C(OC)C=C1)(C#N)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Verapamil hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.55 50
DMSO 24.55 50

Preparing Stock Solutions for Verapamil hydrochloride

The following data is based on the product molecular weight 491.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.07 mL 20.36 mL 40.73 mL
2.5 mM 0.81 mL 4.07 mL 8.15 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
25 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for Verapamil hydrochloride

Certificate of Analysis / Product Datasheet
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References for Verapamil hydrochloride

References are publications that support the biological activity of the product.

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653

Lacinova et al (1995) Interaction of RO-40-5967 and vera. with the stably expressed α1-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 274 54 PMID: 7616442

Ustunes et al (1996) Effects of vera. on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 118 1681 PMID: 8842432

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513

Gordon et al (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 PMID: 32353859

Kania et al (2017) Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism. FEBS J. 284 1370 PMID: 28342290

Taha et al (2021) P-glycoprotein inhibition with verapamil overcomes mometasone resistance in chronic sinusitis with nasal polyps. Rhinology 59 205 PMID: 33459729


If you know of a relevant reference for Verapamil hydrochloride, please let us know.

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Keywords: Verapamil hydrochloride, Verapamil hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, vasodilator, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Cav1.x, Autophagy, Coronavirus, 0654, Tocris Bioscience

11 Citations for Verapamil hydrochloride

Citations are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PLoS One 34 1096 PMID: 23349021

Xia et al (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 252 250 PMID: 21362439

Ferland et al (2017) Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol 88 30 PMID: 27890480

Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967


Do you know of a great paper that uses Verapamil hydrochloride from Tocris? Please let us know.

Reviews for Verapamil hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Inhibits calcium influx.
By Mohammad Alqudah on 10/19/2022
Assay Type: In Vitro
Species: Human

Used to inhibit calcium influx in an organ bath at 10 uM. Was dissolved in water. Good inhibition

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