Verapamil hydrochloride

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Cat.No. 0654 - Verapamil hydrochloride | C27H38N2O4.HCl | CAS No. 152-11-4
Description: Ca2+ channel blocker (L-type)
Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

L-type calcium channel blocker. Vasodilator, adrenergic antagonist.

Technical Data

M. Wt 491.07
Formula C27H38N2O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 152-11-4
PubChem ID 62969
InChI Key DOQPXTMNIUCOSY-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(C=C1OC)C(CCCN(C)CCC1=CC(OC)=C(OC)C=C1)(C#N)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.55 50
ethanol 24.55 50
water 24.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 491.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.36 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88 PMID: 8574653

Lacinova et al (1995) Interaction of RO-40-5967 and verapamil with the stably expressed α1-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 274 54 PMID: 7616442

Ustunes et al (1996) Effects of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 118 1681 PMID: 8842432

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513


If you know of a relevant reference for Verapamil hydrochloride, please let us know.

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Keywords: Verapamil hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, vasodilator, Voltage-gated, Calcium, Channels, Autophagy, Voltage-gated, Calcium, Channels, Tocris Bioscience

6 Citations for Verapamil hydrochloride

Citations are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

Azab et al (2015) Binding of ╬▒herpesvirus Glycoprotein H to Surface ╬▒4╬▓1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. FEMS Immunol Med Microbiol 6 PMID: 26489864

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Cereb Cortex 10 e0121634 PMID: 25803863

Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PLoS One 34 1096 PMID: 23349021

Xia et al (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 252 250 PMID: 21362439

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4 e6723 PMID: 19696927

Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. Carcinogenesis 47 296 PMID: 16831218


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Pathways for Verapamil hydrochloride

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