Verapamil hydrochloride

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Cat.No. 0654 - Verapamil hydrochloride | C27H38N2O4.HCl | CAS No. 152-11-4
Description: CaV1.x blocker
Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Purity: ≥99% (HPLC)
Citations (11)
Literature (3)

Biological Activity for Verapamil hydrochloride

Verapamil hydrochloride is a L-type calcium channel blocker. Vasodilator, adrenergic antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Verapamil hydrochloride

M. Wt 491.07
Formula C27H38N2O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 152-11-4
PubChem ID 62969

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Verapamil hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 24.55 50
DMSO 24.55 50

Preparing Stock Solutions for Verapamil hydrochloride

The following data is based on the product molecular weight 491.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.07 mL 20.36 mL 40.73 mL
2.5 mM 0.81 mL 4.07 mL 8.15 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
25 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for Verapamil hydrochloride

Certificate of Analysis / Product Datasheet
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References for Verapamil hydrochloride

References are publications that support the biological activity of the product.

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653

Lacinova et al (1995) Interaction of RO-40-5967 and vera. with the stably expressed α1-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 274 54 PMID: 7616442

Ustunes et al (1996) Effects of vera. on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 118 1681 PMID: 8842432

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513

Gordon et al (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 PMID: 32353859

If you know of a relevant reference for Verapamil hydrochloride, please let us know.

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View all CaV1.x Channel (L-type) Blockers

Keywords: Verapamil hydrochloride, Verapamil hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, vasodilator, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Cav1.x, Autophagy, Coronavirus, 0654, Tocris Bioscience

11 Citations for Verapamil hydrochloride

Citations are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

Bragança et al (2016) Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol 7 45 PMID: 27014060

Dhillon et al (2013) Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs. PLoS One 8 e60552 PMID: 23579446

Azab et al (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. FEMS Immunol Med Microbiol 6 PMID: 26489864

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Cereb Cortex 10 e0121634 PMID: 25803863

Do you know of a great paper that uses Verapamil hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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