Torin 1

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Description: Potent and selective mTOR inhibitor
Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98% (HPLC)
Citations (249)
Reviews (2)
Literature (2)
Pathways (1)

Biological Activity for Torin 1

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for Torin 1

M. Wt 607.62
Formula C35H28F3N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1222998-36-8
PubChem ID 49836027
Smiles O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Torin 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 0.61 1 with gentle warming

Preparing Stock Solutions for Torin 1

The following data is based on the product molecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 164.58 mL 822.88 mL 1645.77 mL
0.05 mM 32.92 mL 164.58 mL 329.15 mL
0.1 mM 16.46 mL 82.29 mL 164.58 mL
0.5 mM 3.29 mL 16.46 mL 32.92 mL

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Product Datasheets for Torin 1

Certificate of Analysis / Product Datasheet
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References for Torin 1

References are publications that support the biological activity of the product.

Guertin and Sabatini (2009) The pharmacology of mTOR inhibition. Sci.Signal. 2 pe24 PMID: 19383975

Thoreen et al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J.Biol.Chem. 284 8023 PMID: 19150980

Liu et al (2010) Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem. 53 7146 PMID: 20860370

Peterson et al (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146 408 PMID: 21816276

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Weichhart et al (2011) Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117 4273 PMID: 21368289

Li et al (2011) mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am.J.Physiol.Cell Physiol. 301 C213 PMID: 21508335

If you know of a relevant reference for Torin 1, please let us know.

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Keywords: Torin 1, Torin 1 supplier, Torin1, mtor, mammalian, target, rapamycin, inhibitors, inhibits, potent, selective, autophagy, mTOR, Autophagy, 4247, Tocris Bioscience

249 Citations for Torin 1

Citations are publications that use Tocris products. Selected citations for Torin 1 include:

Lisa B et al (2022) Measuring Autophagic Cargo Flux with Keima-Based Probes. Methods Mol Biol 2445 99-115 PMID: 34972988

Jose A et al (2022) The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. Autophagy 18 2333-2349 PMID: 35230915

Noboru et al (2022) A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag. Elife 11 PMID: 35938926

Joo-Yeon et al (2022) SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores. Autophagy 18 1613-1628 PMID: 34720018

Yan et al (2022) LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J 41 e108119 PMID: 35099830

Frank et al (2022) Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites 12 PMID: 36144235

Koji L et al (2022) Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins. EMBO Rep 23 e54801 PMID: 35417087

Peter et al (2022) Local anesthetics elicit immune-dependent anticancer effects. J Immunother Cancer 10 PMID: 35483744

Catherine et al (2022) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain 145 4368-4384 PMID: 36039535

Daniel J et al (2022) SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusion. Cell Death Dis 13 953 PMID: 36371383

Chin-Lee et al (2022) Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. iScience 25 105458 PMID: 36388985

Florian A et al (2022) Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy. Autophagy 18 1486-1502 PMID: 34740308

Alessandra et al (2022) Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors. Cancers (Basel) 14 PMID: 35406574

Devrim et al (2022) A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep 12 8134 PMID: 35581289

Philip G et al (2022) Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Life Sci Alliance 5 PMID: 35121625

Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429

Jing et al (2022) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep 40 111092 PMID: 35858571

Xinyi et al (2022) Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner. FEBS Open Bio 12 118-129 PMID: 34614303

Florian et al (2022) mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1. Nat Commun 13 4685 PMID: 35948564

Adriana et al (2022) 3D chromatin remodeling potentiates transcriptional programs driving cell invasion. Proc Natl Acad Sci U S A 119 e2203452119 PMID: 36037342

Jun et al (2019) Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol 202 1428-1440 PMID: 30692212

Arzu et al (2019) MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy 15 375-390 PMID: 30290719

Dong-Hyung et al (2019) Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis 10 952 PMID: 31844040

Seyed Mehdi et al (2019) Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep 29 3620-3635.e7 PMID: 31825840

Charles A et al (2019) Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol 15 776-785 PMID: 31285595

Masaya et al (2019) NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression. Cell Rep 28 1282-1295.e8 PMID: 31365870

Andrea et al (2019) TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy 15 151-164 PMID: 30145926

Scott R et al (2019) Mammalian cell growth dynamics in mitosis. Elife 8 PMID: 31063131

Conrad C et al (2019) VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy 15 1082-1099 PMID: 30654731

Hua et al (2019) Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy 15 1954-1969 PMID: 30894069

Daniel S et al (2019) ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol 21 1206-1218 PMID: 31548609

Andreas et al (2019) The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. J Biol Chem 294 8197-8217 PMID: 30926605

Roberto J et al (2019) Lysophosphatidic acid represses autophagy in prostate carcinoma cells. Biochem Cell Biol 97 387-396 PMID: 30403494

Hayama et al (2018) Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB. J Immunol 200 3790 PMID: 29686050

Lundquist et al (2018) Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell 70 531 PMID: 29727621

Ha et al (2018) Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance. Mol Cancer Res 16 894 PMID: 29453318

Zuzow et al (2018) Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell PMID: 29540532

Xia et al (2016) TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J 35 121 PMID: 26702100

Torgersen et al (2016) The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget 7 86871 PMID: 27894086

Liu (2016) Characterizing inactive ribosomes in translational profiling. Translation (Austin) 4 e1138018 PMID: 27335722

Mao et al (2016) IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. Blood 128 1475 PMID: 27465917

Kimura et al (2016) Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals Nature Communications 7 13130 PMID: 27731330

Gandin et al (2016) nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res 26 636 PMID: 26984228

Xu et al (2016) TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. Autophagy 12 1118 PMID: 27172002

Pai et al (2016) TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress. Oncotarget 7 85365 PMID: 27863419

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Choi et al (2016) Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy 12 1631 PMID: 27314664

Ricoult et al (2016) Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene 35 1250 PMID: 26028026

Zhang et al (2014) Development of a novel method for quantification of autophagic protein degradation by AHA labeling. PLoS Genet 10 901 PMID: 24675368

Sharma et al (2014) Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Arthritis Rheumatol 10 1637 PMID: 25046112

Bernard et al (2014) Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Cell Cycle 10 2193 PMID: 25495560

Li et al (2014) Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. J Exp Med 9 e104809 PMID: 25347447

Liang et al (2014) Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med 211 2249 PMID: 25288394

Li et al (2014) OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. BMC Biochem 211 15 PMID: 24395886

Zullo et al (2014) Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. Proc Natl Acad Sci U S A 15 4 PMID: 24528777

Martina et al (2012) MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8 903 PMID: 22576015

Fonseca et al (2012) Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem 287 17530 PMID: 22474287

Yumei et al (2023) A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell 83 57-73.e9 PMID: 36608670

Atsushi et al (2023) TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney. JCI Insight 8 PMID: 36649084

Markus et al (2023) Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition. Int J Mol Sci 24 PMID: 36675180

Sandra L et al (2023) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience 26 105965 PMID: 36824274

Wendy H et al (2023) Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathol 145 749-772 PMID: 37115208

Rachel et al (2023) TFEB-dependent lysosome biogenesis is required for senescence. EMBO J 42 e111241 PMID: 36970883

Giancarlo et al (2023) RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun 14 2775 PMID: 37188688

Jing et al (2020) The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling. J Cell Sci PMID: 34005139

Wonho et al (2020) Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K). J Biol Chem 295 2336-2347 PMID: 31959630

Steven P et al (2020) 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. Mol Cell 80 828-844.e6 PMID: 33128871

David C et al (2020) mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR. Cell Rep 33 108564 PMID: 33378666

Yan et al (2020) Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis. Autophagy 16 1683-1696 PMID: 31826695

Satoru et al (2020) Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. Nat Struct Mol Biol 27 1194-1201 PMID: 33106659

Jingxin et al (2020) Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos. Sci Adv 6 eaaz0298 PMID: 32426495

Pier Paolo et al (2020) A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome. Nature 585 597-602 PMID: 32612235

Bae Hwan et al (2020) Effects of mTOR inhibitors on neuropathic pain revealed by optical imaging of the insular cortex in rats. Brain Res 1733 146720 PMID: 32061737

Anne et al (2020) Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation. Cell Rep 32 108154 PMID: 32937139

Derya et al (2020) Decoy exosomes provide protection against bacterial toxins. Nature 579 260-264 PMID: 32132711

Jun et al (2020) Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment. EMBO J 39 e103790 PMID: 32567735

Chen et al (2020) LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol 22 246-256 PMID: 32015438

Christopher J et al (2020) BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Rep 31 107474 PMID: 32294437

Jing et al (2020) The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling. J Cell Sci 133 PMID: 32295849

Asma et al (2020) Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proc Natl Acad Sci U S A 117 9477-9482 PMID: 32300016

Ignacio et al (2020) CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Rep 33 108545 PMID: 33357429

Cosima T et al (2020) The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases. Cell Death Differ 27 310-328 PMID: 31142807

Guido et al (2020) Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy. Cell Death Dis 11 433 PMID: 32513922

Valerie et al (2020) MITF and TFEB cross-regulation in melanoma cells. PLoS One 15 e0238546 PMID: 32881934

Florian et al (2020) Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun 11 5133 PMID: 33046706

JoAnn et al (2020) Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun 11 6088 PMID: 33257668

Jürg et al (2020) The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1. Cell Rep 30 3240-3249.e4 PMID: 32160533

Sang Gyun et al (2020) Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Nat Commun 11 1416 PMID: 32184389

Jurre J et al (2020) Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition. Cell Rep 30 2729-2742.e4 PMID: 32101748

Di et al (2020) Macropinocytosis drives T cell growth by sustaining the activation of mTORC1. Nat Commun 11 180 PMID: 31924779

Vladimir et al (2020) De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy. Autophagy 16 1044-1060 PMID: 31517566

Louis-Philippe et al (2020) Microglial metabolic flexibility supports immune surveillance of the brain parenchyma. Nat Commun 11 1559 PMID: 32214088

Laboucarié et al (2017) TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability. EMBO Rep 18 2197 PMID: 29079657

Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599

Sobol et al (2017) Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Mol Cancer Res 15 117 PMID: 27864334

Nguyen et al (2017) DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell 42 9 PMID: 28697336

Cooper et al (2017) TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Res 77 5077 PMID: 28716898

Hong et al (2017) PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol 216 4217 PMID: 29030394

Hung et al (2017) Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife 6 PMID: 29239720

Martina and Puertollano (2013) Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol 200 475 PMID: 23401004

Gammoh et al (2013) Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol 20 144 PMID: 23262492

Bachar-Wikstrom et al (2013) Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 62 1227 PMID: 23274896

Kok et al (2013) Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. J Lipid Res 54 1662 PMID: 23505321

Krajcovic et al (2013) mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell 24 3736 PMID: 24088573

Carnevale et al (2013) SYK regulates mTOR signaling in AML. Leukemia 27 2118 PMID: 23535559

Dai et al (2013) mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev 27 301 PMID: 23388827

Narvajas et al (2013) Epigenetic regulation of autophagy by the methyltransferase G9a. Mol Cell Biol 33 3983 PMID: 23918802

Zhou et al (2013) Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res 23 508 PMID: 23337583

Li et al (2013) Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. J Biol Chem 288 35769 PMID: 24174532

Lambelet et al (2018) Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis. Cell Death Dis 9 96 PMID: 29367588

Mason et al (2018) Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. PLoS One 13 e0190105 PMID: 29329306

Tol et al (2018) HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy 14 437 PMID: 29455584

Georgilis et al (2018) PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell 34 85 PMID: 29990503

Napolitano et al (2018) mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun 9 3312 PMID: 30120233

Barutcu et al (2018) Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy 14 1586 PMID: 29950132

Kim et al (2018) Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis 9 1060 PMID: 30333475

Shi et al (2018) Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Nat Commun 9 4987 PMID: 30478271

Li et al (2018) Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?. J Cancer 9 3373 PMID: 30271499

Gubbiotti et al (2018) Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. J Biol Chem 293 16940 PMID: 30049794

Schwartz et al (2017) Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J Immunol 198 3181 PMID: 28264968

Pei et al (2017) The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy 13 2041 PMID: 29251248

Gupta et al (2017) PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell 65 999 PMID: 28306514

Sciarretta et al (2015) mTORC2 regulates cardiac response to stress by inhibiting MST1. Elife 11 125 PMID: 25843706

Shi et al (2015) Hedgehog signaling activates a positive feedback mechanism involving Ins-like growth factors to induce osteoblast differentiation. Front Behav Neurosci 112 4678 PMID: 25825734

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Chem Biol 9 62 PMID: 25814944

Thorne et al (2015) GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Mol Biol Cell 11 58 PMID: 25402767

Toops et al (2015) Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. J Exp Med 26 41640 PMID: 25378587

Yang et al (2015) PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Clin Invest 212 253 PMID: 25624444

Dasgupta et al (2015) Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. Sci Signal 125 1174 PMID: 25664849

Chung et al (2015) The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Mol Cancer Res 8 ra34 PMID: 25872869

Dey-Guha et al (2015) A mechanism for asymmetric cell division resulting in proliferative asynchronicity. Autophagy 13 223 PMID: 25582703

Matsuzawa et al (2015) TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Sci Rep 11 1052 PMID: 26043155

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Nature 11 547 PMID: 25714760

Rebsamen et al (2015) SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Autophagy 519 477 PMID: 25561175

Figueroa et al (2015) Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Autophagy 67 966 PMID: 25605458

Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Autophagy 14 2285 PMID: 25945415

Sobol et al (2015) Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. J Cell Physiol 230 1064 PMID: 25283437

Valvezan et al (2014) Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7 63 PMID: 24092877

Sahani et al (2014) Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy 10 431 PMID: 24394643

Zaccara et al (2014) p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death Differ PMID: 24926617

Su et al (2014) An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog 10 e1004196 PMID: 24945378

Yamamoto et al (2014) Fertilization-induced autophagy in mouse embryos is independent of mTORC1. Biol Reprod 91 7 PMID: 24855105

Hatanaka et al (2014) Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes 63 3404 PMID: 24834975

Carolyn et al (2021) The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. Nucleic Acids Res 49 458-478 PMID: 33332560

Michael G et al (2021) The DNA methyltransferase DNMT3A contributes to autophagy long-term memory. Autophagy 17 1259-1277 PMID: 32876528

Sung Hoon et al (2021) TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy 17 761-778 PMID: 32167007

Anne-Claude et al (2021) Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. J Cell Biol 220 PMID: 33464297

Yang et al (2021) Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nat Commun 12 508 PMID: 33479206

Torsten et al (2021) pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells. Mol Biol Cell 32 131-142 PMID: 33237838

Juan et al (2021) Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype. Int J Mol Sci 22 PMID: 33921734

Hanna et al (2021) A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Autophagy 17 3124-3139 PMID: 33249983

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We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

0.076–500 nM Torin

review image

inhibition of Torin in acute brain slices.
By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slices

We used Torin-1 to inhibit torin signalling, we got the expected effect on metabolic changes in acute brain slices

30 minute pre-incubation on acute slices

Literature in this Area

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for Torin 1

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.