Torin 1

Pricing Availability   Qty
Description: Potent and selective mTOR inhibitor
Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (249)
Reviews (2)
Literature (2)
Pathways (1)

Biological Activity for Torin 1

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for Torin 1

M. Wt 607.62
Formula C35H28F3N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1222998-36-8
PubChem ID 49836027
InChI Key AKCRNFFTGXBONI-UHFFFAOYSA-N
Smiles O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Torin 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.61 1 with gentle warming

Preparing Stock Solutions for Torin 1

The following data is based on the product molecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 164.58 mL 822.88 mL 1645.77 mL
0.05 mM 32.92 mL 164.58 mL 329.15 mL
0.1 mM 16.46 mL 82.29 mL 164.58 mL
0.5 mM 3.29 mL 16.46 mL 32.92 mL

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Product Datasheets for Torin 1

Certificate of Analysis / Product Datasheet
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References for Torin 1

References are publications that support the biological activity of the product.

Guertin and Sabatini (2009) The pharmacology of mTOR inhibition. Sci.Signal. 2 pe24 PMID: 19383975

Thoreen et al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J.Biol.Chem. 284 8023 PMID: 19150980

Liu et al (2010) Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem. 53 7146 PMID: 20860370

Peterson et al (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146 408 PMID: 21816276

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Weichhart et al (2011) Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117 4273 PMID: 21368289

Li et al (2011) mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am.J.Physiol.Cell Physiol. 301 C213 PMID: 21508335


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Keywords: Torin 1, Torin 1 supplier, Torin1, mtor, mammalian, target, rapamycin, inhibitors, inhibits, potent, selective, autophagy, mTOR, Autophagy, 4247, Tocris Bioscience

249 Citations for Torin 1

Citations are publications that use Tocris products. Selected citations for Torin 1 include:

Kimura et al (2016) Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals Nature Communications 7 13130 PMID: 27731330

Pema et al (2016) mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex. Mol Biol Cell 7 10786 PMID: 26931735

Saric et al (2016) mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Autophagy 27 321 PMID: 26582390

Hao et al (2016) An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. Proc Natl Acad Sci U S A 5 PMID: 27268300

Chen et al (2016) Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. PLoS One 6 28423 PMID: 27328819

Ma et al (2016) The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. PLoS One 11 e0156239 PMID: 27227887

Zhang et al (2016) A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. Cell Rep 12 e1005848 PMID: 27120463

Michael et al (2021) Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells. FASEB J 35 e21909 PMID: 34547144

Jun et al (2021) Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol 207 65-76 PMID: 34135057

Guido et al (2021) Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade. Cell Death Differ 28 1733-1752 PMID: 33335289

Joshua D et al (2021) mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Mol Cell 81 2064-2075.e8 PMID: 33756105

John M et al (2021) mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Mol Cell 81 2076-2093.e9 PMID: 33756106

Costas A et al (2021) Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab 33 1013-1026.e6 PMID: 33609439

Hans-Uwe et al (2021) Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis. J Invest Dermatol 141 2838-2848.e4 PMID: 34090855

Joel D et al (2021) Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. Autophagy 17 3740-3752 PMID: 33706671

John M et al (2021) The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife 10 PMID: 33646118

Konstantinos et al (2021) Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun 12 2424 PMID: 33893293

Sami J et al (2021) Development of a specific live-cell assay for native autophagic flux. J Biol Chem 297 101003 PMID: 34303705

Andrew et al (2021) Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep 36 109636 PMID: 34469722

Neysan et al (2021) Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway. Commun Biol 4 831 PMID: 34215848

Shuang et al (2021) Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis. Nat Commun 12 5214 PMID: 34471131

An-Dao et al (2021) mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic Acids Res 49 3461-3489 PMID: 33398329

Mathilde et al (2021) Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response. Mol Brain 14 87 PMID: 34082793

Selim et al (2021) Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci 18 137-149 PMID: 33390782

M et al (2021) Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence. Nat Commun 12 5507 PMID: 34535653

Päivi et al (2021) FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62. Mol Neurobiol 58 5438-5458 PMID: 34328616

Mario et al (2021) Increased fidelity of protein synthesis extends lifespan. Cell Metab 33 2288-2300.e12 PMID: 34525330

John M et al (2021) Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab 53 101309 PMID: 34303878

Markus et al (2021) p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Cell Stress 5 176-182 PMID: 34917890

Qiong et al (2021) Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol 6 PMID: 34145066

Carolyn et al (2021) The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. Nucleic Acids Res 49 458-478 PMID: 33332560

Michael G et al (2021) The DNA methyltransferase DNMT3A contributes to autophagy long-term memory. Autophagy 17 1259-1277 PMID: 32876528

Sung Hoon et al (2021) TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy 17 761-778 PMID: 32167007

Anne-Claude et al (2021) Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. J Cell Biol 220 PMID: 33464297

Yang et al (2021) Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nat Commun 12 508 PMID: 33479206

Torsten et al (2021) pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells. Mol Biol Cell 32 131-142 PMID: 33237838

Juan et al (2021) Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype. Int J Mol Sci 22 PMID: 33921734

Hanna et al (2021) A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Autophagy 17 3124-3139 PMID: 33249983

Koji L et al (2021) NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Nat Commun 12 3292 PMID: 34078910

David C et al (2021) Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner. Dev Cell 56 1961-1975.e5 PMID: 34107300

Jing et al (2021) Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell 81 4191-4208.e8 PMID: 34686314

Boyang et al (2021) Generation of mouse-human chimeric embryos. Nat Protoc 16 3954-3980 PMID: 34215863

Roberto et al (2021) NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Dev Cell 56 260-276.e7 PMID: 33308480

Paul F et al (2021) Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation. Dev Cell 56 811-825.e6 PMID: 33725483

Sahani et al (2014) Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy 10 431 PMID: 24394643

Valvezan et al (2014) Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7 63 PMID: 24092877

Zaccara et al (2014) p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death Differ PMID: 24926617

Su et al (2014) An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog 10 e1004196 PMID: 24945378

Yamamoto et al (2014) Fertilization-induced autophagy in mouse embryos is independent of mTORC1. Biol Reprod 91 7 PMID: 24855105

Hatanaka et al (2014) Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes 63 3404 PMID: 24834975

Laboucarié et al (2017) TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability. EMBO Rep 18 2197 PMID: 29079657

Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599

Sobol et al (2017) Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Mol Cancer Res 15 117 PMID: 27864334

Nguyen et al (2017) DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell 42 9 PMID: 28697336

Cooper et al (2017) TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Res 77 5077 PMID: 28716898

Hong et al (2017) PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol 216 4217 PMID: 29030394

Hung et al (2017) Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife 6 PMID: 29239720

Gandin et al (2016) nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res 26 636 PMID: 26984228

Xu et al (2016) TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. Autophagy 12 1118 PMID: 27172002

Pai et al (2016) TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress. Oncotarget 7 85365 PMID: 27863419

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Choi et al (2016) Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy 12 1631 PMID: 27314664

Ricoult et al (2016) Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene 35 1250 PMID: 26028026

Xia et al (2016) TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J 35 121 PMID: 26702100

Mao et al (2016) IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. Blood 128 1475 PMID: 27465917

Torgersen et al (2016) The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget 7 86871 PMID: 27894086

Liu (2016) Characterizing inactive ribosomes in translational profiling. Translation (Austin) 4 e1138018 PMID: 27335722

Sica et al (2019) Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Cell Rep 27 820 PMID: 30995479

Neubert et al (2019) HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy 1 PMID: 30982460

Wong et al (2015) Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun 6 8048 PMID: 26310906

Sagnier et al (2015) Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. J Virol 89 615 PMID: 25339774

Ma et al (2015) Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress. Mol Cell Biol 35 956 PMID: 25561470

Jung et al (2015) Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol 35 2479 PMID: 25963655

Grassi et al (2015) Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. Cell Death Dis 6 e1880 PMID: 26355343

Newton et al (2015) Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner. Autophagy 11 1594 PMID: 26259639

Torres-Ayuso et al (2015) Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1. Oncogenesis 4 e164 PMID: 26302180

Fields et al (2015) HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci 35 1921 PMID: 25653352

Avey et al (2015) Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication. PLoS Pathog 11 e1004993 PMID: 26133373

Askvig and Watt (2015) The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures. J Cell Commun Signal 9 217 PMID: 25698661

Xu et al (2013) Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis. Autophagy 9 1418 PMID: 23748697

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. Nat Commun 64 4361 PMID: 23963679

Esen et al (2013) WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab 17 745 PMID: 23623748

Lambelet et al (2018) Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis. Cell Death Dis 9 96 PMID: 29367588

Mason et al (2018) Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. PLoS One 13 e0190105 PMID: 29329306

Tol et al (2018) HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy 14 437 PMID: 29455584

Georgilis et al (2018) PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell 34 85 PMID: 29990503

Napolitano et al (2018) mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun 9 3312 PMID: 30120233

Barutcu et al (2018) Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy 14 1586 PMID: 29950132

Kim et al (2018) Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis 9 1060 PMID: 30333475

Shi et al (2018) Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Nat Commun 9 4987 PMID: 30478271

Li et al (2018) Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?. J Cancer 9 3373 PMID: 30271499

Gubbiotti et al (2018) Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. J Biol Chem 293 16940 PMID: 30049794

Noboru et al (2022) A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag. Elife 11 PMID: 35938926

Joo-Yeon et al (2022) SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores. Autophagy 18 1613-1628 PMID: 34720018

Yan et al (2022) LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J 41 e108119 PMID: 35099830

Frank et al (2022) Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites 12 PMID: 36144235

Koji L et al (2022) Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins. EMBO Rep 23 e54801 PMID: 35417087

Peter et al (2022) Local anesthetics elicit immune-dependent anticancer effects. J Immunother Cancer 10 PMID: 35483744

Catherine et al (2022) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain 145 4368-4384 PMID: 36039535

Daniel J et al (2022) SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusion. Cell Death Dis 13 953 PMID: 36371383

Chin-Lee et al (2022) Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. iScience 25 105458 PMID: 36388985

Florian A et al (2022) Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy. Autophagy 18 1486-1502 PMID: 34740308

Alessandra et al (2022) Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors. Cancers (Basel) 14 PMID: 35406574

Devrim et al (2022) A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep 12 8134 PMID: 35581289

Philip G et al (2022) Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Life Sci Alliance 5 PMID: 35121625

Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429

Jing et al (2022) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep 40 111092 PMID: 35858571

Xinyi et al (2022) Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner. FEBS Open Bio 12 118-129 PMID: 34614303

Florian et al (2022) mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1. Nat Commun 13 4685 PMID: 35948564

Adriana et al (2022) 3D chromatin remodeling potentiates transcriptional programs driving cell invasion. Proc Natl Acad Sci U S A 119 e2203452119 PMID: 36037342

Jun et al (2019) Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol 202 1428-1440 PMID: 30692212

Arzu et al (2019) MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy 15 375-390 PMID: 30290719

Dong-Hyung et al (2019) Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis 10 952 PMID: 31844040

Seyed Mehdi et al (2019) Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep 29 3620-3635.e7 PMID: 31825840

Charles A et al (2019) Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol 15 776-785 PMID: 31285595

Masaya et al (2019) NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression. Cell Rep 28 1282-1295.e8 PMID: 31365870

Andrea et al (2019) TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy 15 151-164 PMID: 30145926

Scott R et al (2019) Mammalian cell growth dynamics in mitosis. Elife 8 PMID: 31063131

Conrad C et al (2019) VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy 15 1082-1099 PMID: 30654731

Hua et al (2019) Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy 15 1954-1969 PMID: 30894069

Daniel S et al (2019) ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol 21 1206-1218 PMID: 31548609

Andreas et al (2019) The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. J Biol Chem 294 8197-8217 PMID: 30926605

Roberto J et al (2019) Lysophosphatidic acid represses autophagy in prostate carcinoma cells. Biochem Cell Biol 97 387-396 PMID: 30403494

Francipane and Lagasse (2013) Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. Oncotarget 4 1948 PMID: 24185040

Morita et al (2013) mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab 18 698 PMID: 24206664

Fournier et al (2013) Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Mol Cell Biol 33 2285 PMID: 23547259

Schwartz et al (2017) Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J Immunol 198 3181 PMID: 28264968

Pei et al (2017) The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy 13 2041 PMID: 29251248

Gupta et al (2017) PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell 65 999 PMID: 28306514

Shi et al (2015) Hedgehog signaling activates a positive feedback mechanism involving Ins-like growth factors to induce osteoblast differentiation. Front Behav Neurosci 112 4678 PMID: 25825734

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Chem Biol 9 62 PMID: 25814944

Thorne et al (2015) GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Mol Biol Cell 11 58 PMID: 25402767

Toops et al (2015) Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. J Exp Med 26 41640 PMID: 25378587

Yang et al (2015) PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Clin Invest 212 253 PMID: 25624444

Dasgupta et al (2015) Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. Sci Signal 125 1174 PMID: 25664849

Chung et al (2015) The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Mol Cancer Res 8 ra34 PMID: 25872869

Dey-Guha et al (2015) A mechanism for asymmetric cell division resulting in proliferative asynchronicity. Autophagy 13 223 PMID: 25582703

Matsuzawa et al (2015) TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Sci Rep 11 1052 PMID: 26043155

Figueroa et al (2015) Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Autophagy 67 966 PMID: 25605458

Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Autophagy 14 2285 PMID: 25945415

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Nature 11 547 PMID: 25714760

Rebsamen et al (2015) SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Autophagy 519 477 PMID: 25561175

Sobol et al (2015) Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. J Cell Physiol 230 1064 PMID: 25283437

Lisa B et al (2022) Measuring Autophagic Cargo Flux with Keima-Based Probes. Methods Mol Biol 2445 99-115 PMID: 34972988

Jose A et al (2022) The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3. Autophagy 18 2333-2349 PMID: 35230915

Martina et al (2014) The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal 7 ra9 PMID: 24448649

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We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

0.076–500 nM Torin

review image

inhibition of Torin in acute brain slices.
By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slices

We used Torin-1 to inhibit torin signalling, we got the expected effect on metabolic changes in acute brain slices

30 minute pre-incubation on acute slices


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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for Torin 1

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.