You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PI 103 hydrochloride
Inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 384.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.99 mL||64.97 mL||129.93 mL|
|1 mM||2.6 mL||12.99 mL||25.99 mL|
|2 mM||1.3 mL||6.5 mL||12.99 mL|
|10 mM||0.26 mL||1.3 mL||2.6 mL|
References are publications that support the biological activity of the product.
Fan et al (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 9 341 PMID: 16697955
Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 125 733 PMID: 16647110
Raynaud et al (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 67 5840 PMID: 17575152
Fan et al (2010) Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 3 ra81 PMID: 21062993
If you know of a relevant reference for PI 103 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PI 103 hydrochloride, PI 103 hydrochloride supplier, inhibitors, inhibits, DNA-PK, mTOR, PI, 3-kinase, DNA-Dependent, Protein, Kinases, Mammalian, Target, Rapamycin, PI103, hydrochloride, 3-Kinase, DNA-dependent, Kinase, Inositol, Lipids, Checkpoint, Control, Autophagy, 2930, Tocris Bioscience
8 Citations for PI 103 hydrochloride
Citations are publications that use Tocris products. Selected citations for PI 103 hydrochloride include:
Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Virol 64 4361 PMID: 23963679
Peng et al (2012) Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta. PLoS One 7 e47572 PMID: 23077641
Campbell et al (2013) P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS One 8 e53982 PMID: 23382862
Makhortova et al (2011) A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol 7 544 PMID: 21685895
Guo et al (2017) Epigenetic resetting of human pluripotency. Development 144 2748 PMID: 28765214
Brown et al (2014) Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. PLoS One 88 13149 PMID: 25187540
Li et al (2014) Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. J Exp Med 9 e104809 PMID: 25347447
Li et al (2014) OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. Pain 211 15 PMID: 24395886
Do you know of a great paper that uses PI 103 hydrochloride from Tocris? Please let us know.
Reviews for PI 103 hydrochloride
There are currently no reviews for this product. Be the first to review PI 103 hydrochloride and earn rewards!
Have you used PI 103 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.