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LYN 1604 dihydrochloride
Biological Activity for LYN 1604 dihydrochloride
LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.
Technical Data for LYN 1604 dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LYN 1604 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LYN 1604 dihydrochloride
The following data is based on the product molecular weight 657.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||15.21 mL||76.04 mL||152.08 mL|
|0.5 mM||3.04 mL||15.21 mL||30.42 mL|
|1 mM||1.52 mL||7.6 mL||15.21 mL|
|5 mM||0.3 mL||1.52 mL||3.04 mL|
Product Datasheets for LYN 1604 dihydrochloride
References for LYN 1604 dihydrochloride
References are publications that support the biological activity of the product.
Zhang et al (2021) ULK1 suppresses osteoclast differentiation and bone resorption via inhibiting Syk-JNK through DOK3. Oxid.Med.Cell Longev. 2021 2896674 PMID: 34820053
Zhang et al (2018) UNC-51-like Kinase 1: from an autophagic initiator to multifunctional drug target. J.Med.Chem. 61 6491 PMID: 29509411
Zhang et al (2017) Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem.Sci. 8 2687 PMID: 28553505
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Keywords: LYN 1604 dihydrochloride, LYN 1604 dihydrochloride supplier, LYN1604, potent, UNC-51-like, kinase, 1, ULK1, agonists, agonism, activators, activates, autophagy, apoptosis, Other, Kinases, Autophagy, Apoptosis, Inducers, 6617, Tocris Bioscience
Citations for LYN 1604 dihydrochloride
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