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Biological Activity for Perifosine
Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.
Technical Data for Perifosine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Perifosine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Perifosine
The following data is based on the product molecular weight 461.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.17 mL||10.83 mL||21.66 mL|
|5 mM||0.43 mL||2.17 mL||4.33 mL|
|10 mM||0.22 mL||1.08 mL||2.17 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References for Perifosine
References are publications that support the biological activity of the product.
Delgado-Ramírez et al (2016) Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68 457 PMID: 26922553
Fu et al (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 69 8967 PMID: 19920197
Tazzari et al (2008) Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 68 9394 PMID: 19010914
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Keywords: Perifosine, Perifosine supplier, PKB, Akt, inhibitors, inhibts, lipid, rafts, MAPK, autophagy, apoptosis, induces, inducers, Kv2.1, antitumor, orally, bioavailable, inward, rectifier, potassium, current, KRX-0401, (Protein, Kinase, B), Protein, B/Akt, Autophagy, Voltage-Gated, Potassium, Channels, 6087, Tocris Bioscience
1 Citation for Perifosine
Citations are publications that use Tocris products. Selected citations for Perifosine include:
George et al (2021) Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep 35 109168 PMID: 34038728
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Literature in this Area
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