You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Perifosine
Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.
Technical Data for Perifosine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Perifosine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Perifosine
The following data is based on the product molecular weight 461.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.17 mL||10.83 mL||21.66 mL|
|5 mM||0.43 mL||2.17 mL||4.33 mL|
|10 mM||0.22 mL||1.08 mL||2.17 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References for Perifosine
References are publications that support the biological activity of the product.
Delgado-Ramírez et al (2016) Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68 457 PMID: 26922553
Fu et al (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 69 8967 PMID: 19920197
Tazzari et al (2008) Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 68 9394 PMID: 19010914
If you know of a relevant reference for Perifosine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Perifosine, Perifosine supplier, PKB, Akt, inhibitors, inhibts, lipid, rafts, MAPK, autophagy, apoptosis, induces, inducers, Kv2.1, antitumor, orally, bioavailable, inward, rectifier, potassium, current, KRX-0401, (Protein, Kinase, B), Protein, B/Akt, Autophagy, Voltage-Gated, Potassium, Channels, 6087, Tocris Bioscience
Citations for Perifosine
Citations are publications that use Tocris products.
Currently there are no citations for Perifosine. Do you know of a great paper that uses Perifosine from Tocris? Please let us know.
Reviews for Perifosine
There are currently no reviews for this product. Be the first to review Perifosine and earn rewards!
Have you used Perifosine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.