Perifosine

Pricing Availability   Qty
Description: PKB/Akt inhibitor; also modulates Kv2.1 current
Alternative Names: KRX-0401
Chemical Name: Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Pathways (1)

Biological Activity for Perifosine

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

Technical Data for Perifosine

M. Wt 461.66
Formula C25H52NO4P
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 157716-52-4
PubChem ID 148177
InChI Key SZFPYBIJACMNJV-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCCCCCOP([O-])(OC1CC[N+](C)(CC1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Perifosine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.17 100
ethanol 46.17 100

Preparing Stock Solutions for Perifosine

The following data is based on the product molecular weight 461.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for Perifosine

References are publications that support the biological activity of the product.

Delgado-Ramírez et al (2016) Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68 457 PMID: 26922553

Fu et al (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 69 8967 PMID: 19920197

Tazzari et al (2008) Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 68 9394 PMID: 19010914


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View all Akt (Protein Kinase B) Inhibitors

Keywords: Perifosine, Perifosine supplier, PKB, Akt, inhibitors, inhibts, lipid, rafts, MAPK, autophagy, apoptosis, induces, inducers, Kv2.1, antitumor, orally, bioavailable, inward, rectifier, potassium, current, KRX-0401, (Protein, Kinase, B), Protein, B/Akt, Autophagy, Voltage-Gated, Potassium, Channels, 6087, Tocris Bioscience

1 Citation for Perifosine

Citations are publications that use Tocris products. Selected citations for Perifosine include:

George et al (2021) Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep 35 109168 PMID: 34038728


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Pathways for Perifosine

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.