Rilmenidine hemifumarate

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Cat.No. 0790 - Rilmenidine hemifumarate | C10H16N2O.½C4H4O4 | CAS No. 207572-68-7
Description: α2 agonist. Also I1 ligand
Chemical Name: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Possesses greater I1 vs α2 selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data

M. Wt 238.29
Formula C10H16N2O.½C4H4O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 207572-68-7
PubChem ID 45073450
InChI Key LZFATBMLSYHRTC-WXXKFALUSA-N
Smiles OC(=O)\C=C\C(O)=O.C1CC1C(NC1=NCCO1)C1CC1.C1CC1C(NC1=NCCO1)C1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.96 25
ethanol 25
water 5.96 25

Preparing Stock Solutions

The following data is based on the product molecular weight 238.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.98 mL 41.97 mL
5 mM 0.84 mL 4.2 mL 8.39 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bricca et al (1994) Human brain imidazoline receptors: Further characterisation with [3H] clonidine. Eur.J.Pharmacol. 266 25 PMID: 8137880

Bricca et al (1989) Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 163 373 PMID: 2566507

Mammoto et al (1996) Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 117 1744 PMID: 8732285

Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 13 369 PMID: 1413085

Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949


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1 Citation for Rilmenidine hemifumarate

Citations are publications that use Tocris products. Selected citations for Rilmenidine hemifumarate include:

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010


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