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Biological Activity for SRT 1720
SRT 1720 is selective SIRT 1 activator (EC50 = 0.16 μM). SRT 1720 inhibits growth of bladder cancer organoids and xenografts (IC50 = 0.35 μM) and induces autophagy. In vitro, SRT 1720 increases mitochondrial biogenesis and recovery after oxidation injury and reduces palmitate-induced insulin resistance. Also improves survival and healthspan of obese mice.
Technical Data for SRT 1720
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SRT 1720
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SRT 1720
The following data is based on the product molecular weight 469.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||42.59 mL||212.97 mL||425.93 mL|
|0.25 mM||8.52 mL||42.59 mL||85.19 mL|
|0.5 mM||4.26 mL||21.3 mL||42.59 mL|
|2.5 mM||0.85 mL||4.26 mL||8.52 mL|
References for SRT 1720
References are publications that support the biological activity of the product.
Tan et al (2021) SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene 40 6081 PMID: 34471236
Luo et al (2019) Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int.J.Mol.Med. 43 2033 PMID: 30864731
Paramesha et al (2021) Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function. Antioxidants (Basel) 10 338 PMID: 33668369
Funk et al (2010) SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J.Pharmacol.Exp.Ther. 333 593 PMID: 20103585
If you know of a relevant reference for SRT 1720, please let us know.
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Keywords: SRT 1720, SRT 1720 supplier, SRT1720, SIRT1, sirtuins, activators, organoids, xenografts, autophagy, mitochondria, mitochondrial, oxidation, injury, insulin, resistance, Class, III, HDACs, (Sirtuins), Autophagy, 7558, Tocris Bioscience
Citations for SRT 1720
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Currently there are no citations for SRT 1720. Do you know of a great paper that uses SRT 1720 from Tocris? Please let us know.
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Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.