SRT 1720

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Cat.No. 7558 - SRT 1720 | C25H23N7OS | CAS No. 925434-55-5
Description: Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis
Chemical Name: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for SRT 1720

SRT 1720 is selective SIRT 1 activator (EC50 = 0.16 μM). SRT 1720 inhibits growth of bladder cancer organoids and xenografts (IC50 = 0.35 μM) and induces autophagy. In vitro, SRT 1720 increases mitochondrial biogenesis and recovery after oxidation injury and reduces palmitate-induced insulin resistance. Also improves survival and healthspan of obese mice.

Technical Data for SRT 1720

M. Wt 469.56
Formula C25H23N7OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 925434-55-5
PubChem ID 24180125
InChI Key IASPBORHOMBZMY-UHFFFAOYSA-N
Smiles O=C(NC=1C=CC=CC1C=2N=C3SC=C(N3C2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SRT 1720

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.35 5

Preparing Stock Solutions for SRT 1720

The following data is based on the product molecular weight 469.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 42.59 mL 212.97 mL 425.93 mL
0.25 mM 8.52 mL 42.59 mL 85.19 mL
0.5 mM 4.26 mL 21.3 mL 42.59 mL
2.5 mM 0.85 mL 4.26 mL 8.52 mL

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References for SRT 1720

References are publications that support the biological activity of the product.

Tan et al (2021) SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene 40 6081 PMID: 34471236

Luo et al (2019) Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int.J.Mol.Med. 43 2033 PMID: 30864731

Paramesha et al (2021) Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function. Antioxidants (Basel) 10 338 PMID: 33668369

Funk et al (2010) SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J.Pharmacol.Exp.Ther. 333 593 PMID: 20103585


If you know of a relevant reference for SRT 1720, please let us know.

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Keywords: SRT 1720, SRT 1720 supplier, SRT1720, SIRT1, sirtuins, activators, organoids, xenografts, autophagy, mitochondria, mitochondrial, oxidation, injury, insulin, resistance, Class, III, HDACs, (Sirtuins), Autophagy, 7558, Tocris Bioscience

Citations for SRT 1720

Citations are publications that use Tocris products.

Currently there are no citations for SRT 1720. Do you know of a great paper that uses SRT 1720 from Tocris? Please let us know.

Reviews for SRT 1720

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Literature in this Area

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