Everolimus

Pricing Availability Delivery Time Qty
Cat.No. 6188 - Everolimus | C53H83NO14 | CAS No. 159351-69-6
Description: mTOR inhibitor;immunosuppressant
Alternative Names: AD001
Chemical Name: 42-O-(2-Hydroxyethyl)rapamycin
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Technical Data

M. Wt 958.22
Formula C53H83NO14
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 159351-69-6
PubChem ID 100926147
InChI Key HKVAMNSJSFKALM-GKUWKFKPSA-N
Smiles [H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 95.82 100
ethanol 95.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 958.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL
10 mM 0.1 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lane et al (2009) mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 15 1612 PMID: 19223496

Sedrani et al (1998) Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 30 2192 PMID: 9723437

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316


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Keywords: Everolimus, supplier, mTOR, inhibitors, inhibits, immunosuppressants, RAD001, mTOR, Autophagy, mTOR, Tocris Bioscience

Citations for Everolimus

Citations are publications that use Tocris products.

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Pathways for Everolimus

mTOR

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.