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Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 958.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.04 mL||5.22 mL||10.44 mL|
|5 mM||0.21 mL||1.04 mL||2.09 mL|
|10 mM||0.1 mL||0.52 mL||1.04 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the biological activity of the product.
Lane et al (2009) mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 15 1612 PMID: 19223496
Sedrani et al (1998) Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 30 2192 PMID: 9723437
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
If you know of a relevant reference for Everolimus, please let us know.
Keywords: Everolimus, Everolimus supplier, mTOR, inhibitors, inhibits, immunosuppressants, RAD001, Autophagy, 6188, Tocris Bioscience
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