Everolimus

Pricing Availability   Qty
Description: mTOR inhibitor; Immunosuppressant
Alternative Names: RAD001
Chemical Name: 42-O-(2-Hydroxyethyl)rapamycin
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)

Biological Activity for Everolimus

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Technical Data for Everolimus

M. Wt 958.22
Formula C53H83NO14
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 159351-69-6
PubChem ID 100926147
InChI Key HKVAMNSJSFKALM-GKUWKFKPSA-N
Smiles [H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Everolimus

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 95.82 100
ethanol 95.82 100

Preparing Stock Solutions for Everolimus

The following data is based on the product molecular weight 958.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL
10 mM 0.1 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for Everolimus

Certificate of Analysis / Product Datasheet
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References for Everolimus

References are publications that support the biological activity of the product.

Lane et al (2009) mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 15 1612 PMID: 19223496

Sedrani et al (1998) Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 30 2192 PMID: 9723437

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316


If you know of a relevant reference for Everolimus, please let us know.

View Related Products by Product Action

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Keywords: Everolimus, Everolimus supplier, mTOR, inhibitors, inhibits, immunosuppressants, RAD001, Autophagy, 6188, Tocris Bioscience

1 Citation for Everolimus

Citations are publications that use Tocris products. Selected citations for Everolimus include:

Lisa D et al (2023) A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer Discov 13 766-795 PMID: 36576405


Do you know of a great paper that uses Everolimus from Tocris? Please let us know.

Reviews for Everolimus

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for Everolimus

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.