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Everolimus

Cat. No. 6188 Submit a Review Datasheet / COA / SDS
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Description: mTOR inhibitor; Immunosuppressant
Alternative Names: RAD001
Chemical Name: 42-O-(2-Hydroxyethyl)rapamycin
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Everolimus

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Technical Data for Everolimus

M. Wt 958.22
Formula C53H83NO14
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 159351-69-6
PubChem ID 100926147
InChI Key HKVAMNSJSFKALM-GKUWKFKPSA-N
Smiles [H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Everolimus

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 95.82 100
ethanol 95.82 100

Preparing Stock Solutions for Everolimus

The following data is based on the product molecular weight 958.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL
10 mM 0.1 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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Reconstitution Calculator

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References for Everolimus

References are publications that support the biological activity of the product.

Lane et al (2009) mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 15 1612 PMID: 19223496

Sedrani et al (1998) Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 30 2192 PMID: 9723437

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

If you know of a relevant reference for Everolimus, please let us know.

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Keywords: Everolimus, Everolimus supplier, mTOR, inhibitors, inhibits, immunosuppressants, RAD001, Autophagy, 6188, Tocris Bioscience

Citations for Everolimus

Citations are publications that use Tocris products.

Currently there are no citations for Everolimus. Do you know of a great paper that uses Everolimus from Tocris? Please let us know.

Reviews for Everolimus

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Everolimus

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.