Clonidine hydrochloride

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Cat.No. 0690 - Clonidine hydrochloride | C9H9Cl2N3.HCl | CAS No. 4205-91-8
Description: α2 agonist. Also I1 ligand
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (6)

Biological Activity

Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data

M. Wt 266.56
Formula C9H9Cl2N3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 4205-91-8
PubChem ID 20179
InChI Key ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Smiles Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.66 100
DMSO 19.99 75

Preparing Stock Solutions

The following data is based on the product molecular weight 266.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.52 mL
5 mM 0.75 mL 3.75 mL 7.5 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Armitsu et al (1998) Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681 PMID: 9694921

Ernsberger et al (1987) clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1 PMID: 3030779

Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1 PMID: 7883019

Silva et al (1996) Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872 PMID: 8627569

Merck Index 12 2450

Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949


If you know of a relevant reference for Clonidine hydrochloride, please let us know.

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Keywords: Clonidine hydrochloride, Clonidine hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Adrenergic, Alpha-2, Autophagy, 0690, Tocris Bioscience

9 Citations for Clonidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72 PMID: 21241772

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691

Devoto et al (2015) Selective inhibition of DA-β-hydroxylase enhances DA release from noradrenergic terminals in the medial prefrontal cortex. Mol Pain 5 e00393 PMID: 26516613

Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560

Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain 5 11 PMID: 19284549

Cinelli et al (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep 1 e00122 PMID: 24400133

Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal 7 4 PMID: 21219650

Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951


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Reviews for Clonidine hydrochloride

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Behavioral pharmacology studies in rodents.
By Anonymous on 01/04/2018
Assay Type: In Vivo
Species: Rat

Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.

High doses (great than 1 mg/kg) results in self-injurious behavior in rats.


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