Clonidine hydrochloride

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Description: α2 agonist. Also I1 ligand
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity: ≥99% (HPLC)
Citations (9)
Reviews (1)
Literature (2)

Biological Activity for Clonidine hydrochloride

Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data for Clonidine hydrochloride

M. Wt 266.56
Formula C9H9Cl2N3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 4205-91-8
PubChem ID 20179
Smiles Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Clonidine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 26.66 100
DMSO 13.33 50

Preparing Stock Solutions for Clonidine hydrochloride

The following data is based on the product molecular weight 266.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.52 mL
5 mM 0.75 mL 3.75 mL 7.5 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets for Clonidine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Clonidine hydrochloride

References are publications that support the biological activity of the product.

Armitsu et al (1998) Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681 PMID: 9694921

Ernsberger et al (1987) clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1 PMID: 3030779

Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1 PMID: 7883019

Silva et al (1996) Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872 PMID: 8627569

Merck Index 12 2450

Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949

If you know of a relevant reference for Clonidine hydrochloride, please let us know.

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9 Citations for Clonidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:

Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361

Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal 7 4 PMID: 21219650

Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72 PMID: 21241772

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691

Do you know of a great paper that uses Clonidine hydrochloride from Tocris? Please let us know.

Reviews for Clonidine hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Behavioral pharmacology studies in rodents.
By Anonymous on 01/04/2018
Assay Type: In Vivo
Species: Rat

Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.

High doses (great than 1 mg/kg) results in self-injurious behavior in rats.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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