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Biological Activity for XIE62-1004
XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.
Technical Data for XIE62-1004
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for XIE62-1004
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for XIE62-1004
The following data is based on the product molecular weight 399.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.5 mL||62.51 mL||125.03 mL|
|1 mM||2.5 mL||12.5 mL||25.01 mL|
|2 mM||1.25 mL||6.25 mL||12.5 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
References for XIE62-1004
References are publications that support the biological activity of the product.
Zhang et al (2018) ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 9 4373 PMID: 30349045
Cha-Molstad et al (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 8 102 PMID: 28740232
If you know of a relevant reference for XIE62-1004, please let us know.
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Keywords: XIE62-1004, XIE62-1004 supplier, XIE621004, p62, LC3, p62zz, zz, domain, autophagosome, degrader, degradation, degrade, degrades, mutant, AUTAC, huntingtin, Autophagy, Protein, Dimerizers, 7878, Tocris Bioscience
Citations for XIE62-1004
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