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Description: Inducer of autophagy via interaction of p62 and LC3
Chemical Name: 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for XIE62-1004

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

Technical Data for XIE62-1004

M. Wt 399.91
Formula C23H25NO3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2421146-32-7
PubChem ID 126601715

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XIE62-1004

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8 20

Preparing Stock Solutions for XIE62-1004

The following data is based on the product molecular weight 399.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.5 mL 62.51 mL 125.03 mL
1 mM 2.5 mL 12.5 mL 25.01 mL
2 mM 1.25 mL 6.25 mL 12.5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL

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References for XIE62-1004

References are publications that support the biological activity of the product.

Zhang et al (2018) ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 9 4373 PMID: 30349045

Cha-Molstad et al (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 8 102 PMID: 28740232

If you know of a relevant reference for XIE62-1004, please let us know.

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Keywords: XIE62-1004, XIE62-1004 supplier, XIE621004, p62, LC3, p62zz, zz, domain, autophagosome, degrader, degradation, degrade, degrades, mutant, AUTAC, huntingtin, Autophagy, Protein, Dimerizers, 7878, Tocris Bioscience

Citations for XIE62-1004

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.