ABT 263

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Cat.No. 7680 - ABT 263 | C47H55ClF3N5O6S3 | CAS No. 923564-51-6
Description: High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)

Biological Activity for ABT 263

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM). In vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.

Technical Data for ABT 263

M. Wt 974.62
Formula C47H55ClF3N5O6S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 923564-51-6
PubChem ID 24978538
InChI Key JLYAXFNOILIKPP-KXQOOQHDSA-N
Smiles C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT 263

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.46 100

Preparing Stock Solutions for ABT 263

The following data is based on the product molecular weight 974.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL
10 mM 0.1 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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References for ABT 263

References are publications that support the biological activity of the product.

Chen et al (2011) The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol.Cancer Ther. 10 2340 PMID: 21914853

Wang et al (2017) JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer. Oncotarget 8 86312 PMID: 29156797

Tse et al (2008) ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68 3421 PMID: 18451170

Lee et al (2021) Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature 599 283 PMID: 34517409

Chang et al (2016) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat.Med. 22 78 PMID: 26657143


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View all Bcl-2 Family Inhibitors

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Citations for ABT 263

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for ABT 263

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.