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Biological Activity for AUTAC4
AUTAC4 is an autophagy-targeting chimera targeting mitochondria comprising p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.
Sold under license from Tohoku Techno Arch.
Technical Data for AUTAC4
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AUTAC4
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AUTAC4
The following data is based on the product molecular weight 869.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||5.75 mL||28.74 mL||57.47 mL|
|1 mM||1.15 mL||5.75 mL||11.49 mL|
|2 mM||0.57 mL||2.87 mL||5.75 mL|
|10 mM||0.11 mL||0.57 mL||1.15 mL|
References for AUTAC4
References are publications that support the biological activity of the product.
Takahashi et al (2019) AUTACs: cargo-specific degraders using selective autophagy. Mol.Cell. 76 797 PMID: 31606272
If you know of a relevant reference for AUTAC4, please let us know.
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Keywords: AUTAC4, AUTAC4 supplier, mitochondria, degrader, degraders, autophagy, targeting, chimera, down, syndrome, targeted, protein, degradation, ubiquitin-mediated, target, Active, Degraders, Autophagy, Translocator, Protein, 7699, Tocris Bioscience
Citations for AUTAC4
Citations are publications that use Tocris products.
Currently there are no citations for AUTAC4. Do you know of a great paper that uses AUTAC4 from Tocris? Please let us know.
Reviews for AUTAC4
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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