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AUTAC4

Cat. No. 7699 Submit a Review Datasheet / COA / SDS
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Description: Mitochondrial targeting AUTAC Degrader
Chemical Name: N-[(16R)-16-[[[2-Amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-15,18-dioxo-4,7,10-trioxa-14,17-diazanonadec-1-yl]-α-oxo-2-phenyl-1H-indole-3-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AUTAC4

AUTAC4 is an autophagy-targeting chimera targeting mitochondria. Comprises p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.

Licensing Information

Sold under license from Tohoku Techno Arch.

Technical Data for AUTAC4

M. Wt 869.97
Formula C43H48FN9O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2267315-04-6
PubChem ID 137409907
InChI Key IYRHHSZRPVKBSQ-XIFFEERXSA-N
Smiles CC(N[C@H](C(NCCCOCCOCCOCCCNC(C(C1=C(C2=CC=CC=C2)NC3=CC=CC=C13)=O)=O)=O)CSC4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AUTAC4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.4 20

Preparing Stock Solutions for AUTAC4

The following data is based on the product molecular weight 869.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.75 mL 28.74 mL 57.47 mL
1 mM 1.15 mL 5.75 mL 11.49 mL
2 mM 0.57 mL 2.87 mL 5.75 mL
10 mM 0.11 mL 0.57 mL 1.15 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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References for AUTAC4

References are publications that support the biological activity of the product.

Takahashi et al (2019) AUTACs: cargo-specific degraders using selective autophagy. Mol.Cell. 76 797 PMID: 31606272

If you know of a relevant reference for AUTAC4, please let us know.

View Related Products by Target

Keywords: AUTAC4, AUTAC4 supplier, mitochondria, degrader, degraders, autophagy, targeting, chimera, down, syndrome, targeted, protein, degradation, ubiquitin-mediated, target, Autophagy, Translocator, Protein, Other, Degraders, 7699, Tocris Bioscience

Citations for AUTAC4

Citations are publications that use Tocris products.

Currently there are no citations for AUTAC4. Do you know of a great paper that uses AUTAC4 from Tocris? Please let us know.

Reviews for AUTAC4

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia