Torin 2

Pricing Availability   Qty
Cat.No. 4248 - Torin 2 | C24H15F3N4O | CAS No. 1223001-51-1
Description: Potent and selective mTOR inhibitor
Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (12)
Reviews
Literature
Pathways

Biological Activity

Potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Compound Libraries

Torin 2 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 432.4
Formula C24H15F3N4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1223001-51-1
PubChem ID 51358113
InChI Key GUXXEUUYCAYESJ-UHFFFAOYSA-N
Smiles O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.65 20

Preparing Stock Solutions

The following data is based on the product molecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.56 mL 57.82 mL 115.63 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
2 mM 1.16 mL 5.78 mL 11.56 mL
10 mM 0.23 mL 1.16 mL 2.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Liu et al (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J.Med.Chem. 54 1473 PMID: 21322566

Simioni et al (2014) Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 30 10034 PMID: 25296981

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316


If you know of a relevant reference for Torin 2, please let us know.

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Keywords: Torin 2, Torin 2 supplier, Torin2, mtor, mammalian, target, rapamycin, selective, inhibitors, inhibits, mTOR, Autophagy, 4248, Tocris Bioscience

12 Citations for Torin 2

Citations are publications that use Tocris products. Selected citations for Torin 2 include:

Feehan et al (2018) Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cell Signal 52 35 PMID: 30172026

Han et al (2014) Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods 11 86 PMID: 24213167

Ahmed et al (2014) High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma. Carcinogenesis 35 1564 PMID: 24583924

Hwang et al (2013) Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein. J Biol Chem 288 32064 PMID: 24052256

Zullo et al (2014) Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. Cell 15 4 PMID: 24528777

Brown et al (2014) Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. Mol Biol Cell 88 13149 PMID: 25187540

Jennewein et al (2016) Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 7 20016 PMID: 26956048

Martin et al (2014) mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. Am J Physiol Endocrinol Metab 306 E1397 PMID: 24801387

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Virol 64 4361 PMID: 23963679

Toops et al (2015) Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Nat Commun 26 41640 PMID: 25378587

Yu et al (2015) PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. BMC Biochem 6 7212 PMID: 25998442

Hussain et al (2015) Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer. Mol Med 21 466 PMID: 26023849


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Literature in this Area

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Pathways for Torin 2

mTOR

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.