Autophagy Scientific Review

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Autophagy Scientific Review

Molecular Mechanisms, Physiology & Pathology

Patricia Boya and Patrice Codogno

Review excerpt: "Cell homeostasis involves a fine balance between anabolism and catabolism. In cells, the main catabolic pathways are the ubiquitin-proteasome pathway and the autophagy-lysosomal pathway, through which degradation takes place inside lysosomes. Macroautophagy is a highly regulated cellular mechanism for the degradation and recycling of cytoplasmic contents, including proteins, lipids and whole organelles."