Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The α-subunits contain a single pore-forming region and combine to form tetramers.
Voltage-gated Potassium (KV) Channel Modulators |
|
---|---|
Cat. No. | Product Name / Activity |
4949 | MaxiPost |
Potassium channel modulator; exerts subtype-specific effects | |
Voltage-gated Potassium (KV) Channel Inhibitors |
|
Cat. No. | Product Name / Activity |
4687 | ML 252 |
Potent and selective KV7.2 inhibitor; brain penetrant | |
7486 | Roxadustat |
Inhibitor of peak and late components of delayed rectifier potassium currents | |
Voltage-gated Potassium (KV) Channel Activators |
|
Cat. No. | Product Name / Activity |
2867 | Flupirtine maleate |
KV7 channel activator; also GABAA modulator and indirect NMDA antagonist | |
4305 | ICA 069673 |
KV7.2/KV7.3 channel opener | |
4950 | ICA 110381 |
KV7.2/7.3 activator; displays anticonvulsant properties | |
4519 | ML 213 |
KV7.2 and KV7.4 channel opener | |
4777 | ML 277 |
Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current | |
3062 | NS 1643 |
KV11.1 (hERG) channel activator; antiarrhythmic | |
4462 | NS 3623 |
KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic | |
4166 | NS 5806 |
KV4.3 channel activator | |
2830 | PD 118057 |
Selective KV11.1 (hERG) channel activator | |
5083 | QO 58 |
Kv7 channel opener | |
6233 | Retigabine |
KV7 channel activator | |
Voltage-gated Potassium (KV) Channel Blockers |
|
Cat. No. | Product Name / Activity |
0940 | 4-Aminopyridine |
Non-selective KV channel blocker | |
3489 | Astemizole |
Potent KV11.1 (hERG) channel blocker. Also histamine H1 antagonist | |
6318 | Azimilide dihydrochloride |
Kv11.1 (hERG) channel blocker | |
2787 | BAPTA AM |
hKV11.1 (hERG), hKV1.3 and hKV1.5 channel blocker. Also Ca2+ chelator | |
1412 | Chromanol 293B |
IKs blocker. Also blocks ICFTR | |
1475 | (-)-[3R,4S]-Chromanol 293B |
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412) | |
3757 | Dofetilide |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | |
2533 | DPO-1 |
Blocker of KV1.5 channel and IKur current | |
1808 | E-4031 dihydrochloride |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | |
5676 | Guangxitoxin 1E |
Potent Kv2.1 and Kv2.2 channel blocker | |
5011 | HMR 1556 |
Potent and selective Iks channel blocker | |
3899 | JNJ 303 |
Potent and selective IKs blocker | |
4130 | KN 92 |
K+ channel (Kv) blocker. Inactive analog of KN 93 | |
1278 | KN 93 |
K+ channel blocker (KV); also inhibitor of CaM Kinase II | |
1999 | Linopirdine dihydrochloride |
KV7 (KCNQ) channel blocker | |
3563 | Margatoxin |
Potent KV1.3 channel blocker | |
4367 | Psora 4 |
Potent KV1.3 channel blocker | |
3220 | ShK-Dap22 |
Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro | |
3948 | Terfenadine |
KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist | |
3068 | Tetraethylammonium chloride |
Non-selective K+ channel blocker | |
3829 | UK 78282 hydrochloride |
Blocker of KV1.3 and KV1.4 channels | |
2000 | XE 991 dihydrochloride |
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents | |
Other |
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Cat. No. | Product Name / Activity |
5462 | AAQ chloride |
Photoswitchable Kv channel blocker | |
2007 | Fluticasone propionate |
Selective glucocorticoid agonist; KV1 potentiator | |
6087 | Perifosine |
Modulates Kv2.1current; also PKB/Akt inhibitor | |
5470 | QAQ dichloride |
Photoswitchable Nav, Kv and Cav channel blocker |
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming α-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Tocris offers the following scientific literature for Voltage-gated Potassium (KV) Channels to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
KV1.1 (Shaker-related) |
Human | KCNA1 | NM_000217 | Q09470 |
Mouse | Kcna1 | NM_010595 | P16388 | |
Rat | Kcna1 | NM_173095 | P10499 | |
KV1.2 (Shaker-related) |
Human | KCNA2 | NM_004974 | P16389 |
Mouse | Kcna2 | NM_008425 | P35561 | |
Rat | Kcna2 | NM_012970 | P63142 | |
KV1.3 (Shaker-related) |
Human | KCNA3 | NM_002232 | P22001 |
Mouse | Kcna3 | NM_008418 | P16390 | |
Rat | Kcna3 | NM_019270 | P15384 | |
KV1.4 (Shaker-related) |
Human | KCNA4 | NM_002233 | P22459 |
Mouse | Kcna4 | NM_021275 | Q61423 | |
Rat | Kcna4 | NM_012971 | P15385 | |
KV1.5 (Shaker-related) |
Human | KCNA5 | NM_002234 | P22460 |
Mouse | Kcna5 | NM_145983 | Q61762 | |
Rat | Kcna5 | NM_012972 | P19024 | |
KV1.6 (Shaker-related) |
Human | KCNA6 | NM_002235 | P17658 |
Mouse | Kcna6 | NM_013568 | Q61923 | |
Rat | Kcna6 | CH473964 | P17659 | |
KV1.7 (Shaker-related) |
Human | KCNA7 | NM_031886 | Q96RP8 |
Mouse | Kcna7 | NM_010596 | Q17ST2 | |
KV1.8 (Shaker-related) |
Human | KCNA10 | NM_005549 | Q16322 |
Mouse | Kcna10 | NM_001081140 | NP_001074609 | |
KV β1 | Human | KCNAB1 | NM_003471 | Q14722 |
Mouse | Kcnab1 | NM_010597 | P63143 | |
Rat | Kcnab1 | NM_017303 | P63144 | |
KV β2 | Human | KCNAB2 | NM_172130 | Q13303 |
Mouse | Kcnab2 | NM_010598 | P62482 | |
Rat | Kcnab2 | NM_017304 | P62483 | |
KV β3 | Human | KCNAB3 | NM_004732 | O43448 |
Mouse | Kcnab3 | NM_010599 | P97382 | |
Rat | Kcnab3 | NM_031652 | Q63494 | |
KV2.1 (Shab-related) |
Human | KCNB1 | NM_004975 | Q14721 |
Mouse | Kcnb1 | NM_008420 | Q03717 | |
Rat | Kcnb1 | NM_013186 | P15387 | |
KV2.2 (Shab-related) |
Human | KCNB2 | NM_004770 | Q92953 |
Mouse | Kcnb2 | NM_001098528 | A6H8H5 | |
Rat | Kcnb2 | NM_054000 | Q63099 | |
KV3.1 (Shal-related) |
Human | KCNC1 | NM_004976 | P48547 |
Mouse | Kcnc1 | NM_008421 | P15388 | |
Rat | Kcnc1 | NM_012856 | P25122 | |
KV3.2 (Shal-related) |
Human | KCNC2 | NM_153748 | Q96PR1 |
Mouse | Kcnc2 | NM_001025581 | Q14B80 | |
Rat | Kcnc2 | NM_139216 | P22462 | |
KV3.3 (Shal-related) |
Human | KCNC3 | NM_004977 | Q14003 |
Mouse | Kcnc3 | NM_008422 | Q63959 | |
Rat | Kcnc3 | NM_053997 | Q01956 | |
KV3.4 (Shal-related) |
Human | KCNC4 | NM_001039574 | Q03721 |
Mouse | Kcnc4 | NM_145922 | Q8R1C0 | |
KV4.1 (Shaw-related) |
Human | KCND1 | NM_004979 | Q9NSA2 |
Mouse | Kcnd1 | NM_008423 | Q03719 | |
Rat | Kcnd1 | NM_001105748 | NP_001099218 | |
KV4.2 (Shaw-related) |
Human | KCND2 | NM_012281 | Q9NZV8 |
Mouse | Kcnd2 | NM_019697 | Q9Z0V2 | |
Rat | Kcnd2 | NM_031730 | Q63881 | |
KV4.3 (Shaw-related) |
Human | KCND3 | NM_172198 | Q9UK17 |
Mouse | Kcnd3 | NM_001039347 | Q9Z0V1 | |
Rat | Kcnd3 | NM_031739 | Q62897 | |
KV5.1 | Human | KCNF1 | NM_002236 | Q9H3M0 |
Mouse | Kcnf1 | NM_201531 | Q7TSH7 | |
Rat | Kcnf1 | M81783 | XP_001074279 | |
KV6.1 | Human | KCNG1 | NM_002237 | Q9UIX4 |
Mouse | Kcng1 | NM_001081134 | NP_001074603 | |
Rat | Kcng1 | NM_001106545 | NP_001100015 | |
KV6.2 | Human | KCNG2 | NM_012283 | Q9UJ96 |
Mouse | Kcng2 | AK158780 | Q3TYA3 | |
Rat | Kcng2 | NM_001107372 | Q9QYU3 | |
KV6.3 | Human | KCNG3 | NM_172344 | Q8TAE7 |
Mouse | Kcng3 | NM_153512 | P59053 | |
Rat | Kcng3 | NM_001033957 | Q8R523 | |
KV6.4 | Human | KCNG4 | NM_172347 | Q8TDN1 |
Mouse | Kcng4 | NM_025734 | Q80XM3 | |
KV7.1 | Human | KCNQ1 | NM_000218 | P51787 |
Mouse | Kcnq1 | NM_008434 | P97414 | |
Rat | Kcnq1 | NM_032073 | Q9Z0N7 | |
KV7.2 | Human | KCNQ2 | NM_172109 | O43526 |
Mouse | Kcnq2 | NM_001003824 | Q9Z351 | |
Rat | Kcnq2 | NM_133322 | O88943 | |
KV7.3 | Human | KCNQ3 | NM_004519 | O43525 |
Mouse | Kcnq3 | NM_152923 | Q8K3F6 | |
Rat | Kcnq3 | NM_031597 | O88944 | |
KV7.4 | Human | KCNQ4 | NM_004700 | P56696 |
Mouse | Kcnq4 | NM_001081142 | Q9JK97 | |
Rat | Kcnq4 | CH473968 | Q9JK96 | |
KV7.5 | Human | KCNQ5 | NM_019842 | Q9NR82 |
Mouse | Kcnq5 | NM_023872 | Q9JK45 | |
Rat | Kcnq5l | AF525937 | Q8K3W7 | |
KV8.1 | Human | KCNV1 | NM_014379 | Q6PIU1 |
Mouse | Kcnv1 | NM_026200 | Q8BZN2 | |
Rat | Kcnv1 | NM_021697 | P97557 | |
KV9.1 | Human | KCNS1 | NM_002251 | Q96KK3 |
Mouse | Kcns1 | NM_008435 | O35173 | |
Rat | Kcns1 | NM_053954 | O88758 | |
KV9.2 | Human | KCNS2 | NM_020697 | Q9ULS6 |
Mouse | Kcns2 | NM_181317 | O35174 | |
Rat | Kcnq4 | NM_023966 | Q9ER26 | |
KV9.3 | Human | KCNS3 | NM_002252 | Q9BQ31 |
Mouse | Kcns3 | NM_173417 | Q8BQZ8 | |
Rat | Kcns3 | NM_031778 | O88759 | |
KV10.1 (eag1) |
Human | KCNH1 | NM_002238 | O95259 |
Mouse | Kcnh1 | NM_010600 | Q60603 | |
Rat | Kcnh1 | NM_031742 | Q63472 | |
KV10.2 (eag2) |
Human | KCNH5 | NM_139318 | Q8NCM2 |
Mouse | Kcnh5 | NM_172805 | Q920E3 | |
Rat | Kcnh5 | NM_133610 | Q9EPI9 | |
KV11.1 (herg1) |
Human | KCNH2 | NM_000238 | Q12809 |
Mouse | Kcnh2 | NM_013569 | O35219 | |
Rat | Kcnh2 | NM_053949 | O08962 | |
KV11.2 (herg2) |
Human | KCNH6 | NM_030779 | Q9H252 |
Mouse | Kcnh6 | NM_001037712 | NP_001032801 | |
Rat | Kcnh6 | NM_053937 | O54853 | |
KV11.3 (herg3) |
Human | KCNH7 | NM_033272 | Q9NS40 |
Mouse | Kcnh7 | NM_133207 | Q9ER47 | |
Rat | Kcnh7 | NM_131912 | O54852 | |
KV12.1 (elk1) |
Human | KCNH8 | NM_144633 | Q96L42 |
Mouse | Kcnh8 | NM_001031811 | P59111 | |
Rat | Kcnh8 | NM_145095 | Q9QWS8 | |
KV12.2 (elk2) |
Human | KCNH3 | NM_012284 | Q9ULD8 |
Mouse | Kcnh2 | NM_010601 | Q9WVJ0 | |
Rat | Kcnh3 | NM_017108 | O89047 | |
KV12.3 (elk3) |
Human | KCNH4 | NM_012285 | Q9UQ05 |
Mouse | Kcnh4 | NM_001081194 | NP_001074663 | |
Rat | Kcnh4 | NM_053630 | Q9R1T9 | |
minK | Human | KCNE1 | NM_000219 | P15382 |
Mouse | Kcne1 | NM_008424 | P23299 | |
Rat | Kcne1 | NM_012973 | P15383 | /tr>|
KChIP1 | Human | KCNIP1 | NM_014592 | Q9NZI2 |
Mouse | Kcnip1 | NM_027398 | Q9JJ57 | |
Rat | Kcnip1 | NM_022929 | Q8R426 | |
KChIP2 | Human | KCNIP2 | NM_173194 | Q9HD10 |
Mouse | Kcnip2 | NM_145703 | Q9JJ69 | |
Rat | Kcnip2 | NM_020095 | Q9JM59 | |
KChIP3 | Human | KCNIP3 | NM_013434 | Q9Y2W7 |
Mouse | Kcnip3 | NM_001111331 | Q9QXT8 | |
KChIP4 | Human | KCNIP4 | NM_025221 | Q6PIL6 |
Mouse | Kcnip4 | NM_030265 | Q6PHZ8 | |
Rat | Kcnip4 | NM_181365 | Q99MG9 | |
MiRP1 | Human | KCNE2 | NM_172201 | Q9Y6J6 |
Mouse | Kcne2 | NM_134110 | Q9D808 | |
Rat | Kcne2 | NM_133603 | P63161 | |
MiRP2 | Human | KCNE3 | NM_005472 | Q9Y6H6 |
Mouse | Kcne3 | NM_020574 | Q9WTW2 | |
Rat | Kcne3 | NM_022235 | Q9JJV7 | |
MiRP3 | Human | KCNE4 | NM_080671 | Q8WWG9 |
Mouse | Kcne4 | NM_021342 | Q9WTW3 | |
Rat | Kcne4 | NM_212526 | Q71FD8 |