BAPTA AM

Pricing Availability Delivery Time Qty
Cat.No. 2787 - BAPTA AM | C34H40N2O18 | CAS No. 126150-97-8
Description: Cell-permeable Ca2+ chelator
Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Purity: ≥95% (HPLC)
Datasheet
Citations (17)
Literature

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

Technical Data

M. Wt 764.68
Formula C34H40N2O18
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 126150-97-8
PubChem ID 2293
InChI Key YJIYWYAMZFVECX-UHFFFAOYSA-N
Smiles O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.94 30

Preparing Stock Solutions

The following data is based on the product molecular weight 764.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.31 mL 6.54 mL 13.08 mL
5 mM 0.26 mL 1.31 mL 2.62 mL
10 mM 0.13 mL 0.65 mL 1.31 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Raspe et al (1989) Enhanced release of prostacyclin from quin 2-loaded endothelial cells. Eur.J.Pharmacol. 163 345 PMID: 2498111

Tang et al (2007) The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem.Pharmacol. 74 1596 PMID: 17826747

Heilporn et al (1994) Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin. Bull.Soc.Chim.Belg. 103 309 PMID:


If you know of a relevant reference for BAPTA AM, please let us know.

Keywords: BAPTA AM, supplier, Cell-permeable, Ca2+, chelator, hERG, KV11.1, hKv13, hKv15, channels, blockers, Calcium, Signaling, Signalling, Agents, General, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, BAPTAAM, Biochemicals, and, Molecular, Biology, Tocris Bioscience

17 Citations for BAPTA AM

Citations are publications that use Tocris products. Selected citations for BAPTA AM include:

Gong (2017) ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences Cell 169 286 PMID: 28388412

Ahmed (2016) Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. Physiological Reports 4  e13069 PMID: 28039410

Díaz et al (2015) Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212 665 PMID: 25870199

Morais et al (2015) L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. PLoS One 10 e0132569 PMID: 26193352

Pozner et al (2015) Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci 8 12 PMID: 26005403

Draganov et al (2015) Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Nature 5 16222 PMID: 26552848

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Sci Rep 125 1215 PMID: 25664854

Chen et al (2015) Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium. BMC Complement Altern Med 5 18204 PMID: 26659126

Ahn et al (2015) Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. J Biol Chem 15 202 PMID: 26122524

Pecze et al (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. MBio 290 28214 PMID: 26396196

Azab et al (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. J Biol Chem 6 PMID: 26489864

Wang et al (2015) MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. Mol Pharmacol 290 168 PMID: 25416777

Campwala et al (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127 4964 PMID: 25271060

Pandya and Pillai (2014) TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Sci Rep 12 47 PMID: 25052836

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. J Clin Invest 492 123 PMID: 23143333

Kajiya et al (2012) Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. J Clin Biochem Nutr 82 115 PMID: 22511543


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Pathways for BAPTA AM

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