Two-P potassium channels (K2P) are a family of proteins responsible for background potassium currents, which are important in stabilizing membrane potential. Fifteen K2P channels have been identified to date.
Two-P Potassium Channel Modulators |
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Cat. No. | Product Name / Activity |
1540 | DCPIB |
Modulator of K2P channels; activates TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3; also VSAC blocker | |
Two-P Potassium Channel Activators |
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Cat. No. | Product Name / Activity |
3797 | BL 1249 |
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | |
6689 | GI 530159 |
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator | |
6887 | ML 335 |
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | |
6888 | ML 402 |
Selective TREK channel activator | |
6886 | ML 67-33 |
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | |
6484 | Terbinafine hydrochloride |
Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase | |
Two-P Potassium Channel Blockers |
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Cat. No. | Product Name / Activity |
6972 | A 1899 |
Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker | |
5337 | ML 365 |
Potent and selective K2P3.1 (TASK-1) channel blocker | |
5338 | PK-THPP |
Potent K2P9.1 (TASK-3) channel blocker | |
5594 | Spadin |
Potent K2P2.1 (TREK-1) channel blocker |
Two-P potassium channels (K2P) are a family of proteins responsible for background potassium currents, which are important in stabilizing membrane potential. K2Ps are so called because each subunit contains four transmembrane and two pore domains (P loops), although they do not form two pores; it is this 4TM/2P formation that characterizes the members of the K2P channel family. They are thought to form functional dimers within the membrane. Fifteen K2P channels have been identified to date, encoded by KCNK genes. These have been grouped into six subfamilies, TWIK, TREK, TASK, TALK, THIK, and TRESK, based on structural and functional properties.
K2P channels are expressed in the kidney, brain, lung, heart, adrenal cortex and in the auditory and vestibular sensory systems, as well as in smooth muscle cells of the gut, bladder, uterus and vasculature. Under physiological conditions (high intracellular and low extracellular K+ concentration) the potassium current through the K2P channel is predominantly outward. Activity of these channels is regulated by oxygen tension, pH, lipids, temperature, mechanical stretch, neurotransmitters and G protein-coupled receptors. They are considered to have a role in neural development, neuroprotection, pain signal processing and cardioprotection, among numerous other functions. K2Ps are the target for some general and local anesthetics.
Tocris offers the following scientific literature for Two-P Potassium Channels to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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K2p1.1 | Human | KCNK1 | NM_002245 | O00180 |
Mouse | Kcnk1 | NM_008430 | O08581 | |
Rat | Kcnk1 | NM_021688 | Q9Z2T2 | |
K2p2.1 | Human | KCNK2 | NM_014217 | O95069 |
Mouse | Kcnk2 | NM_010607 | P97438 | |
Rat | Kcnk2 | NM_172042 | NP_742039 | |
K2p3.1 | Human | KCNK3 | NM_002246 | O14649 |
Mouse | Kcnk3 | NM_010608 | O35111 | |
Rat | Kcnk3 | NM_033376 | NP_203694 | |
K2p4.1 | Human | KCNK4 | NM_033311 | Q9NYG8 |
Mouse | Kcnk4 | NM_008431 | O88454 | |
Rat | Kcnk4 | NM_053804 | NP_446256 | |
K2p5.1 | Human | KCNK5 | NM_003740 | O95279 |
Mouse | Kcnk5 | NM_021542 | Q9JK62 | |
Rat | Kcnk5 | NM_001039516 | NP_001034605 | |
K2p6.1 | Human | KCNK6 | NM_004823 | Q9Y257 |
Mouse | Kcnk6 | NM_001033525 | Q3TBV4 | |
Rat | Kcnk6 | NM_053806 | NP_446258 | |
K2p7.1 | Human | KCNK7 | NM_005714 | Q9Y2U2 |
Mouse | Kcnk7 | NM_010609 | Q9Z2T1 | |
Rat | Kcnk7 | - | - | |
K2p9.1 | Human | KCNK9 | NM_016601 | Q9NPC2 |
Mouse | Kcnk9 | NM_001033876 | Q3LS21 | |
Rat | Kcnk9 | NM_053405 | NP_445857 | |
K2p10.1 | Human | KCNK10 | NM_021161 | P57789 |
Mouse | Kcnk10 | NM_001316665 | Q3LS20 | |
Rat | Kcnk10 | NM_023096 | Q9JIS4 | |
K2p12.1 | Human | KCNK12 | NM_022055 | Q9HB15 |
Mouse | Kcnk12 | NM_199251 | Q76M80 | |
Rat | Kcnk12 | NM_022292 | NP_071628 | |
K2p13.1 | Human | KCNK13 | NM_022054 | Q9HB14 |
Mouse | Kcnk13 | NM_001164427 | Q8R1P5 | |
Rat | Kcnk13 | NM_022293 | Q9ERS0 | |
K2p15.1 | Human | KCNK15 | NM_022358 | Q9H427 |
Mouse | Kcnk15 | NM_001030292 | B2RVL1 | |
Rat | Kcnk15 | NM_130813 | Q8R5I0 | |
K2p16.1 | Human | KCNK16 | NM_032115 | Q96T55 |
Mouse | Kcnk16 | NM_029006 | G5E845 | |
Rat | Kcnk16 | NM_001109520 | NP_001102990 | |
K2p17.1 | Human | KCNK17 | NM_031460 | Q96T54 |
Mouse | - | - | - | |
Rat | - | - | - | |
K2p18.1 | Human | KCNK18 | NM_181840 | Q7Z418 |
Mouse | Kcnk18 | NM_207261 | Q6VV64 | |
Rat | Kcnk18 | NM_001003820 | Q6Q1P3 |