Two-P Potassium Channels

Two-P potassium channels (K2P) are a family of proteins responsible for background potassium currents, which are important in stabilizing membrane potential. Fifteen K2P channels have been identified to date.

Gene Data

Two-P Potassium Channel Modulators

Cat. No. Product Name / Activity
1540 DCPIB
Modulator of K2P channels; activates TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3; also VSAC blocker

Two-P Potassium Channel Inhibitors

Cat. No. Product Name / Activity
7868 PE 22-28
Potent inhibitor of TREK-1 channels

Two-P Potassium Channel Activators

Cat. No. Product Name / Activity
3797 BL 1249
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
6689 GI 530159
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
6887 ML 335
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
6888 ML 402
Selective TREK channel activator
6886 ML 67-33
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
6484 Terbinafine hydrochloride
Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

Two-P Potassium Channel Blockers

Cat. No. Product Name / Activity
6972 A 1899
Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
8007 C 101248
Selective and potent inhibitor of both mouse and human THIK-1
5337 ML 365
Potent and selective K2P3.1 (TASK-1) channel blocker
5338 PK-THPP
Potent K2P9.1 (TASK-3) channel blocker
5594 Spadin
Potent K2P2.1 (TREK-1) channel blocker

Two-P potassium channels (K2P) are a family of proteins responsible for background potassium currents, which are important in stabilizing membrane potential. K2Ps are so called because each subunit contains four transmembrane and two pore domains (P loops), although they do not form two pores; it is this 4TM/2P formation that characterizes the members of the K2P channel family. They are thought to form functional dimers within the membrane. Fifteen K2P channels have been identified to date, encoded by KCNK genes. These have been grouped into six subfamilies, TWIK, TREK, TASK, TALK, THIK, and TRESK, based on structural and functional properties.

K2P channels are expressed in the kidney, brain, lung, heart, adrenal cortex and in the auditory and vestibular sensory systems, as well as in smooth muscle cells of the gut, bladder, uterus and vasculature. Under physiological conditions (high intracellular and low extracellular K+ concentration) the potassium current through the K2P channel is predominantly outward. Activity of these channels is regulated by oxygen tension, pH, lipids, temperature, mechanical stretch, neurotransmitters and G protein-coupled receptors. They are considered to have a role in neural development, neuroprotection, pain signal processing and cardioprotection, among numerous other functions. K2Ps are the target for some general and local anesthetics.

External sources of pharmacological information for Two-P Potassium Channels :

    Two-P potassium channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    K2p1.1 Human KCNK1 NM_002245 O00180
    Mouse Kcnk1 NM_008430 O08581
    Rat Kcnk1 NM_021688 Q9Z2T2
    K2p2.1 Human KCNK2 NM_014217 O95069
    Mouse Kcnk2 NM_010607 P97438
    Rat Kcnk2 NM_172042 NP_742039
    K2p3.1 Human KCNK3 NM_002246 O14649
    Mouse Kcnk3 NM_010608 O35111
    Rat Kcnk3 NM_033376 NP_203694
    K2p4.1 Human KCNK4 NM_033311 Q9NYG8
    Mouse Kcnk4 NM_008431 O88454
    Rat Kcnk4 NM_053804 NP_446256
    K2p5.1 Human KCNK5 NM_003740 O95279
    Mouse Kcnk5 NM_021542 Q9JK62
    Rat Kcnk5 NM_001039516 NP_001034605
    K2p6.1 Human KCNK6 NM_004823 Q9Y257
    Mouse Kcnk6 NM_001033525 Q3TBV4
    Rat Kcnk6 NM_053806 NP_446258
    K2p7.1 Human KCNK7 NM_005714 Q9Y2U2
    Mouse Kcnk7 NM_010609 Q9Z2T1
    Rat Kcnk7 - -
    K2p9.1 Human KCNK9 NM_016601 Q9NPC2
    Mouse Kcnk9 NM_001033876 Q3LS21
    Rat Kcnk9 NM_053405 NP_445857
    K2p10.1 Human KCNK10 NM_021161 P57789
    Mouse Kcnk10 NM_001316665 Q3LS20
    Rat Kcnk10 NM_023096 Q9JIS4
    K2p12.1 Human KCNK12 NM_022055 Q9HB15
    Mouse Kcnk12 NM_199251 Q76M80
    Rat Kcnk12 NM_022292 NP_071628
    K2p13.1 Human KCNK13 NM_022054 Q9HB14
    Mouse Kcnk13 NM_001164427 Q8R1P5
    Rat Kcnk13 NM_022293 Q9ERS0
    K2p15.1 Human KCNK15 NM_022358 Q9H427
    Mouse Kcnk15 NM_001030292 B2RVL1
    Rat Kcnk15 NM_130813 Q8R5I0
    K2p16.1 Human KCNK16 NM_032115 Q96T55
    Mouse Kcnk16 NM_029006 G5E845
    Rat Kcnk16 NM_001109520 NP_001102990
    K2p17.1 Human KCNK17 NM_031460 Q96T54
    Mouse - - -
    Rat - - -
    K2p18.1 Human KCNK18 NM_181840 Q7Z418
    Mouse Kcnk18 NM_207261 Q6VV64
    Rat Kcnk18 NM_001003820 Q6Q1P3