Flupirtine maleate

Pricing Availability Delivery Time Qty
Cat.No. 2867 - Flupirtine maleate | C15H17FN4O2.C4H4O4 | CAS No. 75507-68-5
Description: KV7 channel activator
Alternative Names: D 9998
Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Compound Libraries

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Technical Data

M. Wt 420.4
Formula C15H17FN4O2.C4H4O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 75507-68-5
PubChem ID 53276
InChI Key JUUFBMODXQKSTD-UHFFFAOYSA-N
Smiles OC(=O)\C=C/C(O)=O.NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(F)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.04 100
ethanol 4.2 10

Preparing Stock Solutions

The following data is based on the product molecular weight 420.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Osborne et al (1998) Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen.Pharmacol. 30 255 PMID: 9510072

Azad et al (2004) The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. Neurosci.Lett. 370 186 PMID: 15488320

Yeung et al (2007) Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity. Br.J.Pharmacol. 151 758 PMID: 17519950

Klinger (2012) Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br.J.Pharmacol. 166 1631 PMID: 22188423


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