HMR 1556

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Description: Potent and selective Iks channel blocker
Chemical Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for HMR 1556

HMR 1556 is a potent and selective Iks channel blocker (IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.

Compound Libraries for HMR 1556

HMR 1556 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HMR 1556

M. Wt 411.44
Formula C17H24F3NO5S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 223749-46-0
PubChem ID 9887834
Smiles CC2(C)[C@H](O)[C@@H](N(S(C)(=O)=O)C)C1=CC(OCCCC(F)(F)F)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HMR 1556

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.14 100

Preparing Stock Solutions for HMR 1556

The following data is based on the product molecular weight 411.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for HMR 1556

Certificate of Analysis / Product Datasheet
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References for HMR 1556

References are publications that support the biological activity of the product.

Gerlach et al (2001) Synthesis and activity of novel and selective I(Ks)-channel blockers. J.Med.Chem. 44 3831 PMID: 11689069

Michael et al (2007) Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br.J.Pharmacol 152 1215 PMID: 17965747

Thomas et al (2003) HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J.Cardiovasc.Pharmacol. 41 140 PMID: 12500032

If you know of a relevant reference for HMR 1556, please let us know.

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Citations for HMR 1556

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Reviews for HMR 1556

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HMR 1556 shortens cardiac action potential duration.
By Anonymous on 05/16/2019
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes

A representative action potential of a guinea pig cardiomyocyte before and after superfusion with 500 nM HMR 1556 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. HMR 1556 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.

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